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常玉曉,，研究員,，博士生導(dǎo)師,，中國(guó)農(nóng)科院“青年英才”,，深圳市“海外高層次人才”,。

2009年畢業(yè)于華中農(nóng)業(yè)大學(xué)作物遺傳改良國(guó)家重點(diǎn)實(shí)驗(yàn)室,，獲理學(xué)博士學(xué)位,。2010-2015年先后在美國(guó)The Wistar Institute和The Jackson Lab for Genomic Medicine從事腫瘤基因組學(xué)研究,。目前主要研究領(lǐng)域?yàn)樾乱淮鷾y(cè)序技術(shù)的開(kāi)發(fā)及應(yīng)用和產(chǎn)業(yè)化，已經(jīng)成功開(kāi)發(fā)出多種新的DNA測(cè)序相關(guān)方法并申請(qǐng)了專利,。近五年以第一/通訊作者在國(guó)際學(xué)術(shù)期刊上發(fā)表學(xué)術(shù)論文5篇,。

研究?jī)?nèi)容：

新一代測(cè)序技術(shù)（Next Generation Sequencing, NGS）的快速發(fā)展已經(jīng)深深的影響了植物功能基因組學(xué)和育種研究的方方面面。隨著測(cè)序技術(shù)的不斷成熟以及價(jià)格的不斷下降,，未來(lái)NGS一定會(huì)與植物功能基因組學(xué)和育種研究結(jié)合的更加緊密,。我們的研究方向主要是基于NGS，開(kāi)發(fā)為植物功能基因組學(xué)和育種研究服務(wù)的新方法,，主要包括：第一,，DNA大片段文庫(kù)的制備；第二,，全基因組分子標(biāo)記的新方法,；第三，這些新技術(shù)在復(fù)雜植物基因組中的應(yīng)用,，尤其是玉米抗病基因定位與克隆中的應(yīng)用,。

研究進(jìn)展：

改良了Fosmid文庫(kù)的構(gòu)建方法，大大提高了Fosmid文庫(kù)的構(gòu)建效率,； 開(kāi)發(fā)了高效的重測(cè)序文庫(kù)構(gòu)建方法AIO-seq,，簡(jiǎn)化了實(shí)驗(yàn)流程，降低了測(cè)序總成本,。

代表論文：

1. Hui Zhang#, Yuexing Wang#, Ce Deng, Sheng Zhao, Peng Zhang, Jie Feng, Wei Huang, Shujing Kang, Qian Qian, Guosheng Xiong*, Yuxiao Chang*. High-quality genome assembly of Huazhan and Tianfeng, the parents of an elite rice hybrid Tian-you-hua-zhan, SCIENCE CHINA Life Sciences, 2021, doi: 10.1007/s11427-020-1940-9.

2.Xinchao Wang#, Hu Feng#, Yuxiao Chang#, Chunlei Ma#, Liyuan Wang#, Xinyuan Hao#, A’lun Li, Hao Cheng , Lu Wang, Peng Cui, Jiqiang Jin, Xiaobo Wang, Kang Wei, Cheng Ai, Sheng Zhao, Zhichao Wu, Youyong Li, Benying Liu, Guodong Wang*, Liang Chen*, Jue Ruan*, Yajun Yang*. Population sequencing enhances understanding of tea plant evolution, Nature communications, 2020, 11(1):4447

3. Sheng Zhao#, Cuicui Zhang#, Jiangqiang Mu, Hui Zhang, Wen Yao, Xinhua Ding, Junqiang Ding*, Yuxiao Chang*. All-in-one sequencing: an improved library preparation method for cost-effective and high-throughput next-generation sequencing, Plant Methods, 2020, 16:74.

4. Meng Lv, Ce Deng, Xueying Li, Xiaodi Zhao, Huimin Li, Zhimin Li, Zhiqiang Tian, April Leonard, Jennifer Jaqueth , Bailin Li, Junjie Hao, Yuxiao Chang, Junqiang Ding*. Identification and fine-mapping of Rppcml496, a major QTL for resistance to Puccinia polysora in maize, The Plant Genome, 2020, e20062

5. Ping Li#, Haoju Liu#, Hong Yang, Xiaojun Pu, Chuanhong Li, Heqiang Huo, Zhaohui Chu, Yuxiao Chang, Yongjun Lin*, Li Liu*. Translocation of Drought-Responsive Proteins from the Chloroplasts, Cells 2020, 9(1), 259.

6. Ce Deng, Huimin Li, Zhimin Li, Zhiqiang Tian, Jiafa Chen, Gengshen Chen, Xuecai Zhang, Junqiang Ding*, Yuxiao Chang*. New QTL for resistance to Puccinia polysora  Underw in maize, Journal of Applied Genetics, 2019, 60: 147-150.

7. Changsong Zou, Leiting Li, Daisuke Miki, Deli Li, Qiming Tang, Lihong Xiao, Santosh Rajput, Ping Deng, Li Peng, Wei Jia, Ru Huang, Meiling Zhang, Yidan Sun, Jiamin Hu, Xing Fu, Patrick S. Schnable, Yuxiao Chang, Feng Li, Hui Zhang, Baili Feng, Xinguang Zhu, Renyi Liu, James C. Schnable, Jiankang Zhu*, Heng Zhang*. The genome of broomcorn millet, Nature Communications, 2019, 10(1): 436-446.

8. Zhiyong Li, Yifeng Wang, Babatunde Kazeem Bello, Abolore Adijat Ajadi, Xiaohong Tong, Yuxiao Chang*, Jian Zhang*. Construction of a Quantitative Acetylomic Tissue Atlas in Rice (Oryza sativa  L.), Molecules, 2018, 23(11): 2843-2859.

9. Xingwang Li, Yuxiao Chang, Xiaodong Xin, Chunmei Zhu, Xianghua Li, James D Higgins, Changyin Wu*. Replication protein A2c coupled with replication protein A1c regulates crossover formation during meiosis in rice, Plant Cell, 2013, 25(10): 3885-3899.

10. Yuxiao Chang, Tuan Long, Changyin Wu*. Effort and contribution of T-DNA Insertion mutant library for rice functional genomics research in China: review and perspective, Journal of Integrative Plant Biology, 2012, 54(12): 953-966.

11. Yanjun Kou, Yuxiao Chang, Xianghua Li, Jinghua Xiao, Shiping Wang*. The rice RAD51C gene is required for the meiosis of both female and male gametocytes and the DNA repair of somatic cells, Journal of Experimental Botany, 2012, 63(14): 5323-5335.

12. Yuxiao Chang, Liang Gong, Wenya Yuan, Xingwang Li, Guoxing Chen, Xianghua Li, Qifa Zhang, Changyin Wu*. Replication protein A (RPA1a) is required for meiotic and somatic DNA repair but is dispensable for DNA replication and homologous recombination in rice, Plant Physiology, 2009, 151(4): 2162-2173.

13. 張翠翠#,，趙勝#，王越,，張鵬,，常玉曉*. 利用高效的大片段 DNA 回收方法改良 Fosmid 文庫(kù)的構(gòu)建，生物技術(shù)通報(bào),，2020, 36(7):17-23.

代表專利：

常玉曉,，趙勝，劉可,。一種一次制備多個(gè)DNA大片段插入雙末端測(cè)序文庫(kù)的方法,，2017.09.05，中國(guó)：ZL201510430638.3

       主要講授課程：生物化學(xué)實(shí)驗(yàn)理論與技術(shù),、作物育種學(xué)專題,。