導(dǎo)師簡介

唐中林,，博士,，研究員，博士生導(dǎo)師,。中國農(nóng)業(yè)科學(xué)院“豬基因組設(shè)計(jì)育種創(chuàng)新團(tuán)隊(duì)”首席科學(xué)家,，中國農(nóng)業(yè)科學(xué)院佛山鯤鵬現(xiàn)代農(nóng)業(yè)研究院執(zhí)行院長,。2006-2017年在中國農(nóng)業(yè)科學(xué)院北京畜牧獸醫(yī)研究所任副研究員,、研究員，2015-2016年在哈佛大學(xué)醫(yī)學(xué)院做訪問學(xué)者,，2018年12月-2021年5月受聘為中國農(nóng)業(yè)科學(xué)院深圳農(nóng)業(yè)基因組研究所動物基因組研究中心主任,。

2014年入選科技部“創(chuàng)新人才推進(jìn)計(jì)劃”領(lǐng)軍人才，2016年入選國家重大人才工程科技創(chuàng)新領(lǐng)軍人才,。目前兼任國際PAG-Asia會議共同主席,、中國畜牧獸醫(yī)學(xué)會動物遺傳育種分會理事、中國畜牧獸醫(yī)學(xué)會養(yǎng)豬分會理事,、中國畜牧獸醫(yī)學(xué)會畜禽遺傳標(biāo)記分會常務(wù)理事和中國實(shí)驗(yàn)動物學(xué)會第一屆無菌動物專業(yè)委員會常務(wù)委員,、全國生豬遺傳改良計(jì)劃專家委員會委員（2021-2035）、第三次全國畜禽遺傳資源普查技術(shù)專家組成員,、“農(nóng)業(yè)部豬肉質(zhì)量安全控制重點(diǎn)實(shí)驗(yàn)室”學(xué)術(shù)委員會副主任,、“廣西壯族自治區(qū)巴馬香豬資源開發(fā)工程研究中心”主任、“廣西家畜遺傳改良重點(diǎn)實(shí)驗(yàn)室”學(xué)術(shù)委員會副主任,，《Frontiers in bioscience》,、《Genes》、《Animals》等多種國際刊物和《中國實(shí)驗(yàn)動物學(xué)報(bào)》編委,，《中國比較醫(yī)學(xué)雜志》通訊編委,。此外，受聘為華中農(nóng)業(yè)大學(xué),、華南農(nóng)業(yè)大學(xué),、廣西大學(xué)、河南大學(xué)等國內(nèi)多個高校的兼職教授,，荷蘭瓦赫寧根大學(xué),、新西蘭都柏林大學(xué)和澳大利亞默多克大學(xué)等多個國外大學(xué)的博士生聯(lián)合導(dǎo)師。主持國家自然科學(xué)基金重點(diǎn)及面上項(xiàng)目,、973子課題,、863重點(diǎn)和轉(zhuǎn)基因重大專項(xiàng)子課題、廣東省重點(diǎn)研發(fā)項(xiàng)目,、廣東省粵深聯(lián)合基金重點(diǎn)項(xiàng)目,、中國農(nóng)科院重大科研任務(wù)等國家及省部級項(xiàng)目近20項(xiàng)；發(fā)表科研論文143篇（其中SCI論文70篇）,，其中以第一作者或通訊作者（含共同）在Genome Biology、Nucleic Acid Research,、JBC和DNA Research等國際知名刊物發(fā)表SCI論文40余篇,，論文被SCI引用1037次，受國外學(xué)者邀請參編專著3本,。作為主要完成人獲國家技術(shù)發(fā)明二等獎,、中國發(fā)明專利銀獎,、中國專利優(yōu)秀獎、廣西科技進(jìn)步二等和三等獎,、中華農(nóng)業(yè)科技獎優(yōu)秀創(chuàng)新團(tuán)隊(duì)獎等國家和省部級獎7項(xiàng),，中國科協(xié)優(yōu)秀論文特等獎1項(xiàng)，獲國際發(fā)明專利1項(xiàng),，國家發(fā)明專利18項(xiàng),，軟件著作權(quán)23項(xiàng)，實(shí)用新型專利1項(xiàng),，作為主要完成人培育豬新品種和配套系3個,。

團(tuán)隊(duì)簡介

豬基因組設(shè)計(jì)育種創(chuàng)新團(tuán)隊(duì)專注于功能基因組與基因組設(shè)計(jì)育種相關(guān)研究。主要包括：綜合利用高通量的基因組,、轉(zhuǎn)錄組,、代謝組、蛋白組等多種組學(xué)技術(shù)和精準(zhǔn)基因編輯技術(shù),，解析豬和小鼠等動物組織器官生長發(fā)育,、產(chǎn)肉性狀、營養(yǎng)利用和抗病等重要經(jīng)濟(jì)性狀形成的分子機(jī)制,；利用生物信息,、分子和細(xì)胞生物學(xué)等手段，在分子,、細(xì)胞和個體水平,，闡明基因和非編碼RNA的功能和表達(dá)調(diào)控機(jī)制；整合多組學(xué)數(shù)據(jù)和全基因組關(guān)聯(lián)分析,，大規(guī)模挖掘豬等動物經(jīng)濟(jì)性狀關(guān)鍵基因和新的遺傳標(biāo)記,；開發(fā)豬全基因組設(shè)計(jì)育種的新理論新方法，開展豬育種新材料創(chuàng)制和品種改良,。

研究成果

1.Adeyinka A. Adetula, Xinhao Fan, Yongsheng Zhang, Yilong Yao, Junyu Yan, Muya Chen, Yijie Tang, Yuwen Liu, Guoqiang Yi, Kui Li & Zhonglin Tang (2021) Landscape of tissue-specific RNA Editome provides insight into co-regulated and altered gene expression in pigs (Sus-scrofa), RNA Biology, DOI: 10.1080/15476286.2021.1954380

2.Yan J, Yang Y, Fan X, Tang Y, Tang Z*. Sp1-Mediated circRNA circHipk2 Regulates Myogenesis by Targeting Ribosomal Protein Rpl7. Genes (Basel). 2021 May 8;12(5):696. doi: 10.3390/genes12050696.

3.Yalan Yang#, Xinhao Fan#, Junyu Yan#, Muya Chen, Min Zhu, Yijie Tang, Siyuan Liu, Zhonglin Tang*. A comprehensive epigenome atlas reveals DNA methylation regulating skeletal muscle development. Nucleic Acids Research. 2020, 49(3):1313-1329

4.Zhou, C.*, Sun, Y.*, Yan, R.*, Liu, Y.*, Zuo, E.*, Gu, C., Han, L., Wei, Y., Hu, X., Zeng, R., Li, Y.#, Zhou, H.#, Guo, F.#, Yang, H.# .(2019).Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis. Nature:571, 275–278

5.Zuo, E.*, Sun, Y.*, Wei, W.*, Yuan, T.*, Ying, W., Sun, H., Yuan, L., Steinmetz, L. M.#, Li, Y.#, Yang, H#.(2019). Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos. Science :364, 289-292.

6.Xinxin Zhang#, Yilong Yao#, Jinghua Han, Yalan Yang, Yun Chen, ZhongLin Tang*, Fei Gao*, Longitudinal epitranscriptome profiling reveals the crucial role of N6-methyladenosine methylation in porcine prenatal skeletal muscle development. Journal of Genetics and Genomics. 2020, 47 (8): 465-476.

7.YongSheng Zhang, YiLong Yao, ZiShuai Wang, Dan Lu, YuanYuan Zhang, Adeyinka Abiola Adetula, SiYuan Liu, Min Zhu, YaLan Yang, XinHao Fan, MuYa Chen, YiJie Tang, Yun Chen, YuWen Liu, GuoQiang Yi, ZhongLin Tang*. MiR-743a-5p regulates differentiation of myoblast by targeting Mob1b in skeletal muscle development and regeneration. Genes & Diseases. 2020, https://doi.org/10.1016/j.gendis.2020.11.018.

8.Guoming Liang, Junyu Yan, Jin Guo, Zhonglin Tang*. Identification of Ovarian Circular RNAs and Differential Expression Analysis between MeiShan and Large White Pigs. Animals. 2020, 10(7):1114.

9.Zhang yongsheng, Lu dan, Liu Yuwen, Yi guoqiang, Tang zhonglin*. The untold story between enhancers and skeletal muscle development. Journal of Integrative Agriculture. 2020, 19(0):2-14.

10.Zishuai Wang, YalanYang, Shuaicheng Li, Kui Li, Zhonglin Tang*. Analysis and Comparison of Long Non-coding RNAs Expressed in the Ovaries of Meishan and Yorkshire pigs. Animal Genetics. 2019, 50(6):660-669.

11.Muya Chen, Yi Long Yao, Yalan Yang, Min Zhu, Yijie Tang, Siyuan Liu, Kui Li and Zhonglin Tang*. Comprehensive Profiles of mRNAs and miRNAs Reveal Molecular Characteristics of Multiple Organ Physiologies and Development in Pigs. Frontiers in Genetics. 2019,10:756.

12.Zishuai Wang, Xikang Feng, Zhonglin Tang*, Shuai Cheng Li *. Genome-Wide Investigation and Functional Analysis of Sus scrofa RNA Editing Sites across Eleven Tissues. Genes (Basel). 2019,30;10(5).

13. Yalan Yang, Min Zhu, Xinhao Fan, Yilong Yao, Junyu Yan,Yijie Tang, Siyuan Liu, Kui Li* and Zhonglin Tang*. Developmental atlas of the RNA editome in Sus scrofa skeletal muscle. DNA Research. 2019, 26(3):261-272.

14. Xiaofei Yu, Zishuai Wang, Hao Sun, Guanglin Niu, Kui Li and Zhonglin Tang*. Long non‐coding MEG3 is a marker for skeletal muscle development and meat production traits in pigs. Animal Genetics. 2018, 49(6):571-578.

15. Guoming Liang, Yalan Yang, Hua Li, Hui Yu, Xunbi Li, Zhonglin Tang* and Kui Li*. LncRNAnet: a comprehensive sus scrofa lncRNA database. Animal Genetics. 2018,49(6):632-635.

16. Guoming Liang, Yalan Yang, Guanglin Niu, Zhonglin Tang*, and Kui Li*. Genome-wide profiling of Sus scrofa circular RNAs across 9 organs and 3 developmental stages, DNA Research. 2017, 24(5):523-535.

17. Zhonglin Tang*, Yang Wu*, Yalan Yang*, Yu-Cheng T. Yang, Zishuai Wang, Jiapei Yuan,Yang Yang, Chaoju Hua, Xinhao Fan, Guanglin Niu, Yubo Zhang, Zhi John Lu & Kui Li. Comprehensive analysis of long non-coding RNAs highlights their spatio-temporal expression patterns and evolutional conservation in Sus scrofa. Scientific Reports. 2017,7, 43166.

18. Yalan Yang, Guoming Liang, Guanglin Niu, Yuanyuan Zhang, Rong Zhou, Yanfang Wang, Yulian Mu, Zhonglin Tang*, Kui Li*. Comparative analysis of DNA methylome and transcriptome of skeletal muscle in lean-, obese-, and mini-type pigs. Scientific Reports. 2017, 7:39883.

19. Guanglin Niu#, Yalan Yang#, YuanYuan Zhang, Chaoju Hua, Zishuai Wang, Zhonglin Tang*, Kui Li. Identifying suitable reference genes for gene expression analysis in developing skeletal muscle in pigs. Peer J. 2016, 4: e2428

20. Yalan Yang, Rong Zhou, Yulian Mu,Xinhua Hou, Zhonglin Tang*, Kui Li. Genome-wide analysis of DNA methylation in obese, lean, and miniature pig breeds. Scientific Reports. 2016;7: 30160.

21. Yalan Yang#, Zhonglin Tang#, Xinhao Fan, Kui Xu, Yulian Mu, Rong Zhou*, Kui Li*. Transcriptome analysis revealed chimeric RNAs, single nucleotide polymorphisms and allele-specific expression in porcine prenatal skeletal muscle. Scientific Reports. 2016; 6:29039.

22. Chaoju Hua#, Zishuai Wang#, Jianbing Zhang, Xing Peng, Xinhua Hou, Yalan Yang, Kui Li, Zhonglin Tang*. SMAD7, antagonist of TGF-beta signaling, is a candidate of prenatal skeletal muscle development and weaning weight in pigs, Molecular Biology Reports. 2016 ,43(4):241-51.

23. Xinhua Hou#, Yalan Yang#, Shiyun Zhu, Chaoju Hua, Rong Zhou, Yulian Mu, Zhonglin Tang*, Kui Li. Comparison of skeletal muscle miRNA and mRNA profiles among three pig breeds. Molecular Genetics and Genomics. 2016,291(2):559-73.

24. Zhang L, Huang Y, Wang M, Guo Y, Liang J, Yang X, Qi W, Wu Y, Si J, Zhu S, Li Z, Li R, Shi C, Wang S, Zhang Q, Tang Zhonglin, Wang L, Li K, Fei JF, Lan G*. Development and Genome Sequencing of a Laboratory-Inbred Miniature Pig Facilitates Study of Human Diabetic Disease. iScience. 2019 Jul 20;19:162-176.

招生專業(yè)

所屬專業(yè)： 生物化學(xué)與分子生物學(xué)  ,、 畜牧

聯(lián)系方式

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