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創(chuàng)新團(tuán)隊(duì)

　　農(nóng)業(yè)生物轉(zhuǎn)錄組與代謝組創(chuàng)新團(tuán)隊(duì)

　　Agricultural Transcriptomics and Metabolomics Innovation Group

　　研究方向　　

　　植物天然產(chǎn)物生物合成與代謝調(diào)控的分子機(jī)制,，對(duì)于農(nóng)作物的品質(zhì)改良,、合成生物學(xué)制造,、個(gè)性化食品以及中醫(yī)藥開發(fā)等國(guó)家重大需求,，均具有重要的意義,。團(tuán)隊(duì)綜合利用合成生物學(xué)理念和多組學(xué)大數(shù)據(jù)分析手段,，整合基因組,、轉(zhuǎn)錄組,、蛋白質(zhì)組及代謝組等信息,，聚焦多組學(xué)分子網(wǎng)絡(luò)的大數(shù)據(jù)挖掘與利用和重要代謝分子的生物途徑解析與人工設(shè)計(jì),，實(shí)現(xiàn)重要活性天然產(chǎn)物的高效發(fā)現(xiàn)、機(jī)制解析,、定向設(shè)計(jì),、生物制造和品種改良育種的潛能釋放,。

　　團(tuán)隊(duì)構(gòu)成　　

　　團(tuán)隊(duì)匯聚了多位從事植物代謝、天然產(chǎn)物合成途徑解析,、植物激素信號(hào)轉(zhuǎn)導(dǎo),、合成生物學(xué)智造、代謝組技術(shù)開發(fā)和生物大數(shù)據(jù)分析等跨學(xué)科的青年創(chuàng)新人才,，平均年齡30歲,。團(tuán)隊(duì)成員朝氣蓬勃、銳意創(chuàng)新,、勇于擔(dān)當(dāng),、團(tuán)結(jié)互助，力爭(zhēng)為解決植物代謝前沿問(wèn)題,、推動(dòng)農(nóng)業(yè)合成生物學(xué)發(fā)展與國(guó)家農(nóng)業(yè)重大需求貢獻(xiàn)力量,。

閆建斌課題組、李偉課題組,、李素華課題組,、賈耿介課題組、鄔倩課題組,、盧洪課題組,、程時(shí)鋒課題組

　　團(tuán)隊(duì)成員代表論文　　

　　1. Yang X, Yan J, Zhang Z, Lin T, Xin T, Wang B, Wang S, Zhao J, Zhang Z, William J, Li G, Huang S. Regulation of plant architecture by a novel histone acetyltransferase targeting gene bodies. Nature Plant, 2020, 6, 809-822.

　　2. Liao Q, Du R, Gou J, Guo L, Shen H, Liu H, Nguyen J, Ray M, Yin T, S. Huang S and Yan J. The genomic architecture of sex determining region and sex-related metabolic variation in Ginkgo biloba. The Plant Journal, 2020, doi.org/10.1111/tpj.15009.

　　3. Li C, Ong K, Cui Z, Sang Z, Li X, Patria R, Qi Q, Fickers P, Yan J and Lin C. Promising advancement in fermentative succinic acid production by yeast hosts, Journal of Hazardous Materials, 2020, 401, 123414.

　　4. Li, C., Chen, C., Wu, X., Tsang, C.W., Mou, J., Yan, J., Liu, Y., Lin, C.S.K., 2019. Recent advancement in lignin biorefinery: with special focus on enzymatic degradation and valorization. Bioresource Technology. 121898.

　　5. Li, C., Ong, K.L., Yang, X., Lin, C.S.K. 2019. Bio-refinery of waste streams for green and efficient succinic acid production by engineered Yarrowia lipolytica without pH control. Chemical Engineering Journal. 371, 804-812.

　　6. Li, C., Yang, X., Gao, S., Lin, C.S.K., 2018. Hydrolysis of fruit and vegetable waste for efficient succinic acid production with engineered Yarrowia lipolytica. Journal of Cleaner Production. 179, 151-159.

　　7. Li, C., Gao, S., Yang, X., Lin, C.S.K., 2017. Green and sustainable succinic acid production from crude glycerol by engineered Yarrowia lipolytica via agricultural residue based in situ fibrous bed bioreactor. Bioresource Technology. 249, 612-619.

　　8. Li, C., Yang, X., Gao, S., Wang, H., Lin, C.S.K., 2017. High efficiency succinic acid production from glycerol via in situ fibrous bed bioreactor with an engineered Yarrowia lipolytica. Bioresource Technology. 225, 9-16.

　　9. Liu, Y., Li, C., Wang, S., Chen, W., 2014. Solid-supported microorganism of Burkholderia cenocepacia cultured via solid state fermentation for biodiesel production: Optimization and kinetics. Applied Energy. 113, 713-721.

　　10. Li W, Daniel B., Zhou F, Robert L., Eran P. Pyrethrin biosynthesis: The cytochrome P450 oxidoreducatse CYP82Q3 converts jasmolone to pyrethrolone. Plant Physiology, 2019,181: 934–944.

　　11. Xu H, Li W, Anthony L., Henri?tte E., Ric C., Maarten A., Eran P. Pyrethric acid of natural pyrethrin insecticide: complete pathway elucidation and reconstitution in Nicotiana benthamiana. New Phytologist, 2019, 223: 751–765.

　　12. Zhu G, Wang S, Huang Z, Zhang S, Liao Q, Zhang C, Lin T, Qin M, Peng M, Yang C, Cao X, Han X, Wang X, Esther K., Zhang Z, Cui X, Harry K., Alisdair R., Luo J, Huang S, Rewiring of the Fruit Metabolome in Tomato Breeding, Cell, 2018, 172, 1, 249-261

　　13. Wu R, Zhang F, Liu L, Li W, Eran P., Wang G. MeNA, controlled by reversible methylation of nicotinate, is an NAD precursor that undergoes long-distance transport in Arabidopsis. Molecular Plant,2018, 11: 1264-1277.

　　14. Li W, Zhou F, Eran P. Jasmone hydroxylase, a key enzyme in the synthesis of the alcohol moiety of pyrethrin insecticides. Plant Physiology, 2018, 177: 1498-1509.

15. Yan J, Yao R, Chen L, Li S, Gu M, Nan F, Xie D. Dynamic perception of jasmonates by the F-box protein COI1. Molecular Plant, 2018, 11, 1237-1247.

　　16. Shang Y, Huang SW. Multi-omics data-driven investigations of metabolic diversity of plant triterpenoids. The Plant Journal, 2018, doi:10.1111/tpj.14132.

　　17. Li H, Yao R, Ma S, Hu S, Li S, Wang Y, Yan C, Xie D, Yan J. Efficient ASK-assisted system for expression and purification of plant F-box proteins. The Plant Journal, 2017, 92(4), 736-743.

　　18. Zhong Y, Xue XF, Liu ZQ, Ma YS, Zeng KW, Ro DK, Bak S, Huang SW, Zhou Y. Shang Y. Developmentally Regulated Glucosylation of Bitter Triterpenoid in Cucumber by the UDP-Glucosyltransferase UGT73AM3. Molecular Plant, 2017, 10(7), 1000-1003.

　　19. Liu XB, Liu YS, Huang P, Ma YS, Qing ZX, Tang Q, Cao HF, Cheng P, Zhen YJ, Zhou Y, Liu JF, Tang ZS, Zhuo YX, Zhang YC, Yu LL, Huang JL, Yang P, Peng Q, Zhang JB, Jiang WK, Zhang ZH, Lin K, Ro DK, Chen XY, Xiong XY, Shang Y, Huang SW, Zeng JG. The Genome of the Medicinal Plant Macleaya Cordata Provides New Insights into Benzylisoquinoline Alkaloid Metabolism. Molecular Plant, 2017, 10(7), 975-989.

　　20. Li W, Zhang F, Wu R, Jia L, Li G, Guo Y, Liu C, Wang G. A novel N-methyltransferase in Arabidopsis appears to feed a conserved pathway for nicotinate detoxification among land plants and is associated with lignin biosynthesis. Plant Physiology, 2017, 174: 1492-1504.

　　21. Zhou Y, Ma YS, Zeng JG, Duan LX, Xue XF, Wang SH, Lin T, Liu ZQ, Zeng KW, Zhong Y, Zhang S, Hu Q, Liu M, Zhang HM, Reed J, Moses T, Liu XY, Huang P, Qing ZX, Liu XB, Tu PF, Kuang HH, Zhang ZH, Osbourn A, Ro DK, Shang Y, Huang SW. Convergence and Divergence of Bitterness Biosynthesis and Regulation in Cucurbitaceae. Nature Plants, 2016, 2(12), 16183.

　　22. Yan J, Li S, Gu M, Yao R, Li Y, Chen J, Yang M, Tong J, Xiao L, Nan F, Xie D. Endogenous bioactive jasmonate is composed of a set of (+)-7-iso-JA-amino acid conjugates. Plant Physiology, 2016, 172(4), 2154-2164.

　　23. Li S, Chen L, Li Y, Yao R, Wang F, Yang M, Gu M, Nan F, Xie D, Yan J. Effect of GR24 stereoisomers on plant development in Arabidopsis. Molecular Plant, 2016, 10(9), 1432-1435.

　　24. Yao R, Ming Z, Yan L, Li S, Wang F, Ma S, Yu C, Yang M, Chen L, Chen L, Li Y, Yan C, Miao D, Sun Y, Yan J, Sun Y, Wang L, Chu J, Fan S, He W, Deng H, Nan F, Li J, Rao Z, Lou Z, Xie D. DWARF14 is a non-canonical hormone receptor for strigolactone. Nature, 2016, 536, 469-473.

　　25. Li W, Zhang F, Chang Y, Zhao T, Schranz ME, Wang G. Nicotinate O-glucosylation is an evolutionarily metabolic trait important for seed germination under stress conditions in Arabidopsis thaliana. The Plant Cell, 2015, 27: 1907-1924.

　　26. Shang Y, Ma YS, Zhou Y, Zhang HM, Duan LX, Chen HM, Zeng JG, Zhou Q, Wang SH, Gu WJ, Liu M, Ren JW, Gu XF, Zhang SP, Wang Y, Yasukawa K, Bouwmeester HJ, Qi XQ, Zhang ZH, Lucas WJ, Huang SW. Biosynthesis, Regulation, and Domestication of Bitterness in Cucumber. Science, 2014, 346(6213): 1084-1088.

　　27. Yan J, Li H, Li S, Yao R, Deng H, Xie Q, Xie D. The Arabidopsis F-Box protein CORONATINE INSENSITIVE1 is stabilized by SCFCOI1 and degraded via the 26S proteasome pathway. The Plant Cell, 2013, 25: 486-498.

　　28. Shang Y, Yan L, Liu ZQ, Mei C, Cao Z Xin Q, Wu FQ, Wang XF, Du SY, Jiang T, Zhang XF, Zhao R, Sun HL, Liu R, Yu YT, Zhang DP. The Mg-Chelatase H Subunit of Arabidopsis Antagonizes a Group of WRKY Transcription Repressors to Relieve ABA-Responsive Genes of Inhibition. Plant Cell, 2010, 22(6): 1909-1935.

　　29. Yan J., Zhang C., Gu M., Bai Z., Zhang W., Qi T. et al. The Arabidopsis CORONATINE INSENSITIVE1 Protein Is a Jasmonate Receptor. The Plant Cell. 2009, 21: 2220-2236.

更新于2022年10月

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