唐中林課題組

　　Tang Zhonglin Lab

　　課題組長

　　唐中林，研究員，博士生導師,。中國農業(yè)科學院農業(yè)基因組研究所首席科學家,。2016年在哈佛大學做訪問學者。承擔國家自然科學基金重點及面上項目、973子課題、863重點和轉基因重大專項等國家級課題10余項，在Genome Biology,、Nucleic Acid Research、DNA Research等刊物發(fā)表SCI論文70余篇,，獲國家技術發(fā)明二等獎,、省科技進步獎、中華農業(yè)科技獎、國家專利銀獎等多項國家及省部級獎,，獲國家發(fā)明專利17項,，軟件著作權23項，國際發(fā)明專利2項,。

　　

　　工作經歷

　　2017.6至今             中國農業(yè)科學院農業(yè)基因組研究所                  研究員,、中心主任       

　　2015.9-2016.8        哈佛大學                                                       訪問學者

　　2014.1-2017.5       中國農業(yè)科學院畜牧獸醫(yī)研究所                      研究員

　　2008.7-2013.12     中國農業(yè)科學院畜牧獸醫(yī)研究所                      副研究員

　　2006.7-2008.6       中國農業(yè)科學院畜牧獸醫(yī)研究所                      博士后

 

　　教育經歷

　　2001.9-2006.6         華中農業(yè)大學              博士       

　　1994.9-1998.6         華中農業(yè)大學              學士       

　　

　　研究方向

　　綜合利用高通量的基因組、轉錄組,、代謝組,、蛋白組等多種組學技術和精準基因編輯技術，解析豬和小鼠等動物骨骼肌生長發(fā)育和重要經濟性狀形成的分子機制,；利用生物信息,、分子和細胞生物學等手段，在分子,、細胞和個體水平,，闡明骨骼肌生長發(fā)育相關基因和非編碼RNA的功能和表達調控機制。

　　

　　研究進展

　　重要進展成果1：公布首個中國地方豬“超清”基因組圖譜,，提供亞洲地方品種陸川豬參考基因組序列；

　　重要進展成果2：整合多組學方法和全基因組關聯(lián)分析鑒定出多個產肉性狀密切相關的基因標記,；

　　重要進展成果3：首次建立豬全基因組RNA編輯位點,、豬骨骼肌甲基化等多個數(shù)據庫。

　　

　　PI

　　Prof. Zhonglin Tang, Doctoral Advisor, research Professor of Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences (CAAS-AGIS), Director of the Animal Genomics Research Center. Prof. Zhonglin Tang has been honored as a leader talent of National “Ten Thousand Talent Program” and visited Harvard University as a visiting scholar in 2016. Prof. Zhonglin Tang has undertaken more than 10 projects supported by Natural Science Foundation of China, including the National Key Project, 973 Sub-topics, etc. More than 70 journal articles were published on prestigious journals, e.g., Genome Biology, Nucleic Acid Research, DNA Research . His team achieved the National Technology Invention Award, Provincial Science and Technology Progress Award, China Agricultural Science and Technology Award, National Patent Silver Award and other national and provincial awards. He also obtained 17 national invention patents, 23 software copyrights and 2 international patents.

　　

　　Working Experience

　　2017.6–Present               Agricultural Genomics Institute at Shenzhen-CAAS               research Professor,，Center director                

　　2015.9–2016.8               Harvard University                                                                    visiting scholar                                                 

　　2014.1–2017.5               Institute of Animal Sciences -CAAS                                        research Professor

　　2008.7–2013.12             Institute of Animal Sciences -CAAS                                        associate professor         

　　2006.7–2008.6               Institute of Animal Sciences -CAAS                                        Postdoctoral Fellow    

　　

　　Education Experience

　　2001.9-2006.6              Huazhong Agricultural University                          Ph.D                   

　　1994.9-1998.6              Huazhong Agricultural University                          Bachelor           

　　

　　Research Interest

　　Using high-throughput genomics, transcriptomics, metabolomics, proteomics, and gene-editing techniques to understand the molecular mechanisms underlying skeletal muscle growth and development in pigs and mice; Using biological information, molecular and cellular biology to elucidate the function and expression regulation mechanisms of skeletal muscle growth and development related genes and non-coding RNAs at the molecular, cellular and individual levels.

　　

　　Major Achievements

　　Published the first "ultra-clear" genomic map of Chinese local pigs(Luchuan pig), and provided the reference genome sequence of Asian local breeds.

　　Identified multiple genetic markers closely related to meat production traits by Integrated the multi-omics method and genome-wide association analysis Significant Progress.

　　Established the world's first database of pig genome genome RNA editing site and pig skeletal muscle methylation.

　　

　　Selected Publication

　　1. Yalan Yang, Xinhao Fan, Junyu Yan, Muya Chen, Min Zhu, Yijie Tang, Siyuan Liu, ZhongLin Tang*. A comprehensive epigenome atlas reveals DNA methylation regulating skeletal muscle development. Nucleic Acid Research , 2020, doi: 10.1093/nar/gkaa1203.　　

　　2.  Xinxin Zhang, Yilong Yao, Jinghua Han, Yalan Yang, Yun Chen, ZhongLin Tang*, Fei Gao*. Longitudinal epitranscriptome profiling reveals the crucial role of N6-methyladenosine methylation in porcine prenatal skeletal muscle development, Journal of Genetics and Genomics , 2020, 47 (2020) 466-476.　　

　　3.  YongSheng Zhang, YiLong Yao, ZiShuai Wang, Dan Lu, YuanYuan Zhang, Adeyinka Abiola Adetula, SiYuan Liu, Min Zhu, YaLan Yang, XinHao Fan, MuYa Chen, YiJie Tang, Yun Chen, YuWen Liu, GuoQiang Yi, ZhongLin Tang*. MiR-743a-5p regulates differentiation of myoblast by targeting Mob1b in skeletal muscle development and regeneration. Genes & Diseases , 2020, https://doi.org/10.1016/j.gendis.2020.11.018.　　

　　4. Liang, G.; Yan, J.; Guo, J.; Tang, Z*. Identification of Ovarian Circular RNAs and Differential Expression Analysis between MeiShan and Large White Pigs. Animals 2020, 10, 1114.　　

　　5. Zhang yongsheng ,Lu dan, Liu Yuwen, Yi guoqiang, Tang zhonglin*. The untold story between enhancers and skeletal muscle development. Journal of Integrative Agriculture , 2020, 19(0):2-14. 

　　6. Yalan Yang, Min Zhu, Xinhao Fan, Yilong Yao, Junyu Yan, Yijie Tang, Siyuan Liu, Kui Li*,and Zhonglin Tang*. Developmental atlas of the RNA editome in Sus scrofa skeletalmuscle. 2019, DNA Research , 2019.  26(3):261-272

　　7. Z Wang*, Y Yang*, S Li, K Li and Z Tang*. Analysis and comparison of long non-coding RNAs expressed in the ovaries of Meishan and Yorkshire pigs.  Animal Genetics ,2019,50(6):660-669.

　　8. Muya Chen?, Yi Long Yao?, Yalan Yang, Min Zhu, Yijie Tang, Siyuan Liu, Kui Li and Zhonglin Tang*. Comprehensive Profiles of mRNAs and miRNAs Reveal Molecular Characteristics of Multiple Organ Physiologies and Development in Pigs.  Front. Genet ,2019, 10:10.3389

　　9. Zishuai Wang,Xikang Feng,Zhonglin Tang* and Shuai Cheng Li*. Genome-Wide Investigation and Functional Analysis of Sus scrofa RNA Editing Sites across Eleven Tissues. 2019, Genes , 10(7):10.3390

　　10. Li Zhang, Yuemeng Huang,Meng Wang, Yafen Guo, Jing Liang,* Xiurong Yang, Wenjing Qi,Yanjun Wu, Jinglei Si, Siran Zhu, Zhe Li, Ruiqiang Li, Chao Shi,* Shuo Wang, Qunjie Zhang,Zhonglin Tang, Lixian Wang, Kui Li, Ji-Feng Fei, and Ganqiu Lan*Development and Genome Sequencing of a Laboratory-Inbred Miniature Pig Facilitates Study of Human Diabetic Disease,  iScience , 2019, 19:162-176

　　11. Xiaofei Yu, Zishuai Wang, Hao Sun, Guanglin Niu, Kui Li and Zhonglin Tang*.Identify long non-coding MEG3 as a candidate for skeletal muscle development and meat production traits in pigs.  Animal Genetics , 2018, 49(6):571-578.

　　12. Guoming Liang, Yalan Yang, Hua Li, Hui Yu, Xunbi Li, Zhonglin Tang* and Kui Li*.LncRNAnet: a comprehensive sus scrofa lncRNA database.  Animal Genetics , 2018, 49(6):632-635.

　　13. Guoming Liang, Yalan Yang, Guanglin Niu, Zhonglin Tang*, and Kui Li*.Genome-wide profiling of Sus scrofa circular RNAs across 9 organs and 3 developmental stages,  DNA Research , 2017,，24(5):523-535.

　　14. Jing Zhang, Zhengzhou Ying, Zhonglin Tang*, Liangqi Long, Kui Li.MicroRNA-148a promotes myogenic differentiation by targeting the ROCK1. Journal of Biological Chemistry . 2012,287 ( 25 ): 21093-101

　　15. Zhonglin Tang, Yong Li, Ping Wan, Xiaoping Li, Shuhong Zhao, Bang Liu, Bin Fan, Mengjin Zhu, Mei Yu, Kui Li. LongSAGE analysis of skeletal muscle at three prenatal stages in Tongcheng and Landrace pigs.  Genome Biology . 2007.8(6):R115

　　

　　Selected Patent

　　1.唐中林，李奎,，化朝舉/一種基于SMAD7基因的豬活體背膘厚標記輔助選擇方法/2019-02-26/中國

　　2. 唐中林,，李奎，趙栓平,，任紅艷/與豬免疫性狀相關的蛋白及其編碼基因及應用/2013-06-12/中國

　　3. 唐中林,，李奎，梁如意,，周榮,，楊述林，敖紅,，牟玉蓮,，崔文濤/輔助評價仔豬初生重和斷奶重的方法及其專用引物/2013-11-13/中國

　　4. 唐中林，孫浩,，李奎,，梁如意/一種鑒定或輔助鑒定豬達100kg體重日齡的方法及其專用試劑盒/2018-11-27/中國

　　5. 李奎，唐中林，孫浩,，梁如意/一種鑒定或輔助鑒定豬100Kg體重眼肌面積的方法及其專用試劑盒/2018-08-17/中國

　　6. 李奎,，鞠輝明，樊俊華,，白立景,，牟玉蓮，楊述林,，唐中林/一種制備同時表達多個基因的轉基因動物的方法/2011-12-14/中國

　　7.Kui Li, Huiming Ju, Junhua Fan, Lijing Bai, Yulian Mu, Shulin Yang, Zhonglin Tang, WentaoCui/Methold for preparing a transgenic animal of simultaneous multiple-gene expression/2012-09-13/國際專利

　　8. 李奎,，李勇，唐中林,，楊述林/一種檢測豬肉質性狀的方法/2010-12-15/中國

　　9. 李奎,，劉華珍，李新云,，唐中林,，楊述林，崔文濤/一種豬免疫性狀相關蛋白及其編碼基因與應用/2010-06-02/中國

　　10.敖紅,，張寧波,，李奎，李勇,，唐中林,，楊述林，儲明星/檢測豬的抗豬瘟病性狀的方法及其專用試劑盒/2013-02-06/中國

　　

　　唐中林課題組更新于2021年3月