高飛課題組

Gao Fei Lab

　　課題組長

　　高飛，研究員,，博士生導(dǎo)師,，農(nóng)業(yè)部農(nóng)業(yè)基因數(shù)據(jù)分析重點(diǎn)實(shí)驗(yàn)室副主任,，中國遺傳學(xué)會表觀遺傳專業(yè)委員會和中國實(shí)驗(yàn)動物學(xué)會無菌動物學(xué)會委員,。長期從事發(fā)育和疾病過程的表觀遺傳控制,；營養(yǎng)與菌群的表觀遺傳效應(yīng)等研究,。在國際SCI學(xué)術(shù)期刊Genome Biology,、Cell Research等發(fā)表論文51篇,，其中第一或通訊作者論文34篇。

 

　　工作經(jīng)歷

　　2015.04–至今        中國農(nóng)業(yè)科學(xué)院農(nóng)業(yè)基因組研究所  團(tuán)隊(duì)首席                            

      2014.10-2015.03   哥本哈根大學(xué)                                 博士后         

　　2011.02-2014.08  華大基因科技有限公司                   團(tuán)隊(duì)首席      

　　2004.02-2011.12  吉林大學(xué)                                       講師          

 

　　教育經(jīng)歷：

　　2008.01-2010.12       奧胡斯大學(xué)                         博士       

　　2004.09-2007.07      中國科學(xué)院北京基因組所     碩士         

　　1999.09-2004.07       解放軍軍需大學(xué)                  學(xué)士        

 

　　研究方向：動物表觀基因組學(xué)新方法開發(fā),，營養(yǎng)與菌群的表觀遺傳效應(yīng),，動物發(fā)育和疾病過程的表觀遺傳調(diào)控。

 

　　研究成績：運(yùn)用針對微量細(xì)胞的全基因組甲基化測序技術(shù),，團(tuán)隊(duì)首次揭示了靈長類哺乳動物早期胚胎發(fā)育的精細(xì)DNA甲基化圖譜表觀遺傳學(xué)調(diào)控機(jī)制,；與哥本哈根大學(xué)及四川農(nóng)業(yè)大學(xué)緊密合作，運(yùn)用多組學(xué)手段論證了營養(yǎng),、抗生素（腸道菌群）對仔豬腸道DNA甲基化及仔豬腸道組織免疫與代謝功能基因的影響,，進(jìn)一步揭示早期腸道喂養(yǎng)會刺激腸道基因甲基化重塑，使腸道快速適應(yīng)環(huán)境,。先后在Cell Research,、Genome Biology、DNA Research,、Journal of Nutritional Biochemistry,、Frontiers in Immunology等國際期刊發(fā)表一系列成果.　　

　　

　    Animal Epigenomics Innovation Team

　　 Chief Scientist：Fei Gao

　　Fei Gao, Principle Investigator, Doctoral Advisor, deputy director of the Key Laboratory of Agricultural Genetic Data Analysis, Ministry of Agriculture, Young talent of the Chinese Academy of Agricultural Sciences, Leading Talent of Shenzhen, member of the Professional Committee of Epigenetics, Genetics Society of China and member of the Aseptic Animal Society, Chinese Association for Laboratory Animal Sciences.

　　Research in Gao Lab focuses on the role of epigenetics in animal development and pathology, especially how environmental factors such as nutrition and microbiota may affect host epigenetics. He has published 51 peer-reviewed papers on international journals including Genome Biology, Cell Research, etc., 34 of which as the first or corresponding author.

 

　　Working Experience

　　Agricultural Genomics Institute at Shenzhen-CAAS                 

　　Principle Investigator                                       2015.04–Present

　　University of Copenhagen        

　　Postdoctoral Fellow                                          2014.10-2015.03

　　BGI      

　　Leader of Epigenetics Group                            2011.02-2014.08

　　University of Jilin                                 

　　Lecturer                                                             2004.02-2011.12

　　

　　Education

　　Aarhus University                                                                  Ph.D                   2008.01-2010.12

　　Beijing Genomics Institute, Chinese Academy of Science    Master               2004.09-2007.07

　　Quartermaster University of PLA                                          Bachelor             1999.09-2004.07

　　　

　　Research Field:

　　1) Development of new methodologies of animal epigenomics,

　　2) Effects of nutrition and microflora on animal epigenome, and

　　3) epigenetic regulation of animal development and pathology.

 

　　Achievements:

　　We have developed a novel whole-genome bisulfite sequencing technology specifically designed for the minute amount of DNA sample, and obtained single-base resolution DNA methylomes of early stages of primate embryos with this technique. In collaboration with Copenhagen University and Sichuan Agricultural University, we validated the effects of nutrition and gut microbiota on DNA methylation and the function of immune and metabolic genes in intestinal tissue of weaned piglets through a multi-omics approach, revealing that early feeding may be important to stimulate the methylation reprogramming of intestinal genes, allowing rapid intestinal adaptation. These work have been published on Cell Research, Genome Biology, DNA Research, Journal of Nutritional Biochemistry, Frontiers in Immunology etc.

　　

　　Selected publications

　　1. Hu Q, Liu C, Zhang D, Wang R, Qin L, Xu Q, Che L, Gao F. Effects of Low-Dose Antibiotics on Gut Immunity and Antibiotic Resistomes in Weaned Piglets. Fronties in Immunology. 2020 Jun 10;11:903. doi: 10.3389/fimmu.2020.00903.　　

　　2. Pan X, Thymann T, Gao F, Sangild PT. Rapid Gut Adaptation to Preterm Birth Involves Feeding-Related DNA Methylation Reprogramming of Intestinal Genes in Pigs. Fronties in Immunology. 2020 Apr 15;11:565. doi: 10.3389/fimmu.2020.00565.　　

　　3. Pan X, Zhang D, Nguyen DN, Wei W, Yu X, Gao F, Sangild PT. Postnatal Gut Immunity and Microbiota Development Is Minimally Affected by Prenatal Inflammation in Preterm Pigs. Fronties in Immunology. 2020 Mar 19;11:420. doi: 10.3389/fimmu.2020.00420.　　

　　4. Zhang D, Hu Q, Liu X, Zou K, Sarkodie EK, Liu X, Gao F. AllEnricher: a comprehensive gene set function enrichment tool for both model and non-model species. BMC Bioinformatics. 2020 Mar 17;21(1):106. doi: 10.1186/s12859-020-3408-y.

　　5. Lianqiang Che, Qi Hu, Ru Wang, Du Zhang, Cong Liu, Yihe Zhang, Guizhong Xin, Zhengfeng Fang, Yan Lin, Shengyu Xu, Bin Feng, Daiwen Chen, De Wu, Fei Gao. Inter-correlated gut microbiota and SCFAs changes upon antibiotics exposure links with rapid body-mass gain in weaned piglet model. Journal of Nutritional Biochemistry 74 (2019) 108246

　　6. X. Pan, D. Gong, F. Gao* & P. T. Sangild*, Diet-dependent changes in the intestinal DNA methylome after introduction of enteral feeding in preterm pigs. Epigenomics. 2018 Apr 1;10(4):395-408

　　7. Pan X, Gong D, Nguyen DN, Zhang X, Hu Q, Lu H, Fredholm M, Sangild PT, Gao F. Early microbial colonization affects DNA methylation of genes related to intestinal immunity and metabolism in preterm pigs. DNA Research 2018, 0(0), 1–10.

　　8.F. Gao, Y. Niu, Y. Eve Sun, H. Lu, Y. Chen, S. Li, Y. Kang, Y. Luo, C. Si, J. Yu, C. Li, N. Sun, W. Si, H. Wang, W. Ji, T. Tan, De novo DNA methylation during monkey pre-implantation embryogenesis, Cell Research (2017) :1-14.

　　

　　

　　高飛課題組更新于2021年3月