賈耿介課題組

Gengjie (Jay) Jia Lab

[email protected]

　　

　　課題組長

　　賈耿介,，研究員,、博士生導師,，入選國際計算生物學協(xié)會。2008年于中國科學技術(shù)大學本科畢業(yè)，2013年在新加坡國立大學和麻省理工學院聯(lián)合培養(yǎng)項目取得博士學位,。研究專長包括生物信息學、健康表型大數(shù)據(jù)（如電子病歷和體檢報告）挖掘,、精準營養(yǎng),、自然語言處理、生物分子網(wǎng)絡建模,、以及多組學數(shù)據(jù)分析,。以第一或通訊（含共同）作者在Nature Computational Science, Nature Communications、Metabolites,、Bioinformatics 等發(fā)表學術(shù)論文,。

　　

研究方向

通過開發(fā)分析多維度健康大數(shù)據(jù)和營養(yǎng)/膳食大數(shù)據(jù)的算法

1. 發(fā)掘復雜疾病亞型（通過共病模式的系統(tǒng)識別和多組學分析），解析其遺傳學基礎,，進一步設計亞型特異的精準營養(yǎng)干預措施,；

2. 描述疾病并發(fā)的模式規(guī)律，建立并發(fā)癥風險預測模型,，尋找最優(yōu)膳食和（或）藥物組合;

3. 闡釋人體消化等系統(tǒng),、其間微生物群落、和食品營養(yǎng)三方的相互作用關系,。

　　工作經(jīng)歷

　　2021/1至今                  中國農(nóng)業(yè)科學院深圳農(nóng)業(yè)基因組研究所,， 研究員

　　2016/6 – 2020/12       芝加哥大學， 博士后

　　2013/1 – 2016/5         CGG公司數(shù)據(jù)處理分部,， 地球物理學家

　　

　　教育經(jīng)歷

　　2008/7 – 2013/1       新加坡-麻省理工學院聯(lián)盟,，化學與制藥工程博士；

　　2011/4 – 2011/10     瑞士蘇黎世聯(lián)邦理工學院,，訪問學習,；

　　2004/9 – 2008/6       中國科學技術(shù)大學，生物學學士,。

 

       代表論文

(#co-first, *co-corresponding)

1.G. Jia#*, Y. Li#, …, X. Gao*, A. Rzhetsky*.  The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci. Nature Computational Science (2023).

 2 .G. Jia, Zhong, X., Im, H.K. et al. Discerning asthma endotypes through comorbidity mapping. Nature Communications 13, 6712 (2022).

      3.G. Jia, Y. Li, H. Zhang, I. Chattopadhyay, A. B. Jensen, D. R. Blair, L. Davis, P. N. Robinson, T. Dahlén, S. Brunak, M. Benson, G. Edgren, N. J. Cox, X. Gao, A. Rzhetsky*, Estimating Heritability and Genetic Correlations from Large Health Datasets in the Absence of Genetic Data, Nature Communications, 10, 5508 (2019).   (*corresponding authors)

      4.G. Jia, G. Stephanopoulos, R. Gunawan*, Ensemble Kinetic Modeling of Metabolic Networks from Dynamic Metabolic Profiles, Metabolites, 2 (4), 891–912 (2012).

      5.G. Jia, G. Stephanopoulos, R. Gunawan*, Incremental Parameter Estimation of Kinetic Metabolic Network Models, BMC Systems Biology, 6, 142 (2012).

      6.G. Jia, G. Stephanopoulos, R. Gunawan*, Parameter Estimation of Kinetic Models from Metabolic Profiles: Two-phase Dynamic Decoupling Method, Bioinformatics, 27 (14), 1964–1970 (2011).

      7.B. Chicoine, A. Rivelli, V. Fitzpatrick*, L. Chicoine, G. Jia, A. Rzhetsky, Prevalence of Common Disease Conditions in a Large Cohort of Individuals with Down Syndrome in the United States, Journal of Patient-Centered Research and Reviews, 8(2), 86-97 (2021).

      8.X. Zhong*, Z. Yin, G. Jia, D. Zhou, Q. Wei, A. Faucon, P. Evans, E. R. Gamazon, B. Li, R. Tao, A. Rzhetsky, L. Bastarache, N. J. Cox*, Electronic Health Record Phenotypes Associated with Genetically Regulated Expression of CFTR and Application to Cystic Fibrosis, Genetics in Medicine, 22, 1191–1200 (2020).

      9.C. Zhang, H. Tu, G. Jia, T. Mukhtar, V. Taylor, A. Rzhetsky, S. Tay*, Ultra-multiplexed Analysis of Single-cell Dynamics Reveals Logic Rules in Differentiation, Science Advances, 5 (2019).

      10.G. Jia, R. Gunawan*, Construction of Kinetic Model Library of Metabolic Networks, IFAC Proceedings, 45 (15), 952-957 (2012).

     11.G. Jia, G. Stephanopoulos*, Incremental Parameter Estimation and Ensemble Kinetic Modeling of Metabolic Networks, Proceedings of AIChE Annual Meeting (2012).

     12.G. Jia, G. Stephanopoulos, R. Gunawan*, Construction of Kinetic Model Library of Metabolic Networks from Dynamic Profiles, 8th International Workshop on Computational Systems Biology (2011).

賈耿介課題組更新于2023年9月