張艷聰課題組

Zhang Yancong Lab

課題組長(zhǎng)

張艷聰,，研究員，博士生導(dǎo)師,。2017年博士畢業(yè)于北京師范大學(xué),，2018年進(jìn)入美國(guó)哈佛大學(xué)微生組學(xué)和計(jì)算生物學(xué)家Curtis Huttenhower教授課題組開(kāi)展博士后研究，并于2022年晉升為美國(guó)麻省理工學(xué)院-哈佛大學(xué)博得研究所（Broad Institute）研究科學(xué)家（Research Scientist）,。長(zhǎng)期從事微生物組數(shù)據(jù)挖掘與解析,，擅長(zhǎng)多組學(xué)數(shù)據(jù)整合與計(jì)算生物學(xué)分析,。近五年來(lái),，在Nature,、Nature Medicine等國(guó)際權(quán)威期刊發(fā)表SCI論文20余篇，其中以獨(dú)立一作發(fā)表在Nature（2022）的研究為解析微生物組分子“暗物質(zhì)”建立了一種全新的研究策略,，2022獲得哈佛醫(yī)學(xué)院華人科學(xué)家杰出研究獎(jiǎng),。

工作經(jīng)歷

2025.02 -               中國(guó)農(nóng)業(yè)科學(xué)院深圳農(nóng)業(yè)基因組研究所研究員

2022.08 - 2025.01 美國(guó)麻省理工學(xué)院-哈佛大學(xué)博得研究所研究科學(xué)家

2018.06 - 2022.08 美國(guó)哈佛大學(xué)&美國(guó)麻省理工學(xué)院-哈佛大學(xué)博得研究所 博士后

教育經(jīng)歷

2012.09 - 2017.06  北京師范大學(xué)生態(tài)學(xué)  理學(xué)博士    

2008.09 - 2012.06  天津師范大學(xué)計(jì)算機(jī)科學(xué)與技術(shù)  工學(xué)學(xué)士

團(tuán)隊(duì)研究方向

1. 開(kāi)發(fā)微生物多組學(xué)分析算法，解析微生物及其代謝產(chǎn)物在微生態(tài)系統(tǒng)中的功能

2. 挖掘關(guān)鍵功能的微生物標(biāo)志物,，闡釋其在宿主健康與生態(tài)環(huán)境中的重要作用

3. 解析菌群-宿主-飲食環(huán)境的互作機(jī)制,，探索基于微生物組的精準(zhǔn)營(yíng)養(yǎng)方案

研究進(jìn)展

腸道菌群, 作為寄居在宿主消化道內(nèi)的微生物復(fù)雜群落,，包含數(shù)量龐大、種類繁多的微小生命體,。但是,，腸道微生物組如何影響人體健康，目前仍存在諸多未知,，大量腸道微生物產(chǎn)物功能未知且體量龐大，亟需進(jìn)一步深入研究,。針對(duì)這個(gè)難點(diǎn),，團(tuán)隊(duì)開(kāi)展了系列工作：1）基于宏基因組數(shù)據(jù)開(kāi)發(fā)了高效鑒別基因功能潛力的分析工具M(jìn)etaWIBELE，揭示了炎癥性腸病中大量未知功能的腸道微生物基因的潛在重要性,，并結(jié)合實(shí)驗(yàn)驗(yàn)證了關(guān)鍵基因的功能（Nature 2022）,；2）進(jìn)而整合宏轉(zhuǎn)錄組、代謝組等多組學(xué)大數(shù)據(jù),，鑒定了腸道微生物基因及代謝產(chǎn)物在炎癥性腸病中的功能活性 (Bioinformatics 2021, Nature 2022, Nature Medicine 2023),。上述工作為基于微生物組的健康維護(hù)和疾病治療提供新的潛在候選靶點(diǎn)。

代表論文

1. , Yancong ZhangAmrisha Bhosle, Sena Bae, Lauren J. McIver, Emma K. Accorsi, Kelsey N. Thompson, Cesar Arze, Ya Wang, Ayshwarya Subramanian, Damian R. Plichta, Ali Rahnavard, Afrah Shafquat, Ramnik J. Xavier, Hera Vlamakis, Wendy S. Garrett, Andy Krueger, Curtis Huttenhower*, Eric A. Franzosa*. Discovery of bioactive microbial gene products in inflammatory bowel disease. Nature, 2022, 606: 754-760.

2. Yancong Zhang, Kelsey N. Thompson, Curtis Huttenhower, Eric A. Franzosa. Statistical approaches for differential expression analysis in metatranscriptomics. Bioinformatics, 2021, 37(Suppl_1): i34-i41.

3. Yancong Zhang#, Kelsey N. Thompson#, Tobyn Branck, Yan Yan, Long H. Nguyen, Eric A. Franzosa*, Curtis Huttenhower*. Metatranscriptomics for the human microbiome and microbial community functional profiling. Annual Review of Biomedical Data Science, 2021, 4: 279-311.

4. Donggi Paik#, Lina Yao#, Yancong Zhang, Sena Bae, Gabriel D. D’Agostino, Minghao Zhang, Eunha Kim, Eric A. Franzosa, Julian Avila-Pacheco, Jordan E. Bisanz, Christopher K. Rakowski, Hera Vlamakis, Ramnik J. Xavier, Peter J. Turnbaugh, Randy S. Longman, Michael R. Krout, Clary B. Clish, Fraydoon Rastinejad, Curtis Huttenhower, Jun R. Huh*, A. Sloan Devlin*. Human gut bacteria produce TH17-modulating bile acid metabolites. Nature, 2022, 603: 907–912.

5. Raaj S. Mehta#, Jared R. Mayers#, Yancong Zhang, Amrisha Bhosle, Nathaniel R. Glasser, Long H. Nguyen, Wenjie Ma, Sena Bae, Tobyn Branck, Kijun Song, Luke Sebastian, Julian Avila Pacheco, Hyuk-Soo Seo, Clary Clish, Sirano Dhe-Paganon, Ashwin N. Ananthakrishnan, Eric A. Franzosa, Emily P. Balskus*, Andrew T. Chan*, Curtis Huttenhower*. Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease. Nature Medicine, 2023, 29.3: 700-709.

6. Amrisha Bhosle, Sena Bae, Yancong Zhang, Eunyoung Chun, Julian Avila-Pacheco, Ludwig Geistlinger, Gleb Pishchany, Jonathan N Glickman, Monia Michaud, Levi Waldron, Clary B Clish, Ramnik J Xavier, Hera Vlamakis, Eric A Franzosa*, Wendy S Garrett*, and Curtis Huttenhower*. Integrated annotation prioritizes metabolites with bioactivity in inflammatory bowel disease. Molecular Systems Biology, 2024, 0: 1-24. 

7. Yancong Zhang, Kui Lin. Phylogeny inference of closely related bacterial genomes: combining the features of both overlapping genes and collinear genomic regions. Evolutionary Bioinformatics, 2015, 11: EBO-S33491.

8. Yancong Zhang, Yan Zhang, Bi-Ru Zhu, Bo-Wen Zhang, Chuan Ni, Da-Yong Zhang, Ying Huang, Erli Pang, Kui Lin. Genome sequences of two closely related strains of Escherichia coli K-12 GM4792. Standards in Genomic Sciences, 2015, 10.1: 1-9.

9. Sun-Yang Park, Chitong Rao, Katharine Z. Coyte, Gavin A. Kuziel, Yancong Zhang, Wentao Huang, Eric A. Franzosa, Jing-Ke Weng, Curtis Huttenhower, Seth Rakoff-Nahoum. Strain-level fitness in the gut microbiome is an emergent property of glycans and a single metabolite. Cell, 2022, 185.3: 513-529.

10. Wei Li*, Saiyu Hang*, Yuan Fang, Sena Bae, Yancong Zhang, Minghao Zhang, Gang Wang, Megan D. McCurry, Munhyung Bae, Donggi Paik, Eric A. Franzosa, Fraydoon Rastinejad, Curtis Huttenhower, Lina Yao#, A. Sloan Devlin#, Jun R. Huh#. A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1. Cell Host & Microbe, 2021, 29.9: 1366-1377.

張艷聰課題組更新于2025年3月