姓名：		王桂榮
	職稱(chēng)：		研究員，博士生導(dǎo)師
	電話(huà)/傳真：		0755-23250160
	電子郵件：		[email protected]
	實(shí)驗(yàn)室主頁(yè)：
	研究方向：		昆蟲(chóng)化學(xué)生態(tài)學(xué)、昆蟲(chóng)與植物互作、農(nóng)業(yè)害蟲(chóng)功能基因組學(xué)

 簡(jiǎn)歷介紹：

王桂榮，研究員，博士生導(dǎo)師。

2002年畢業(yè)于中國(guó)農(nóng)業(yè)科學(xué)院農(nóng)業(yè)昆蟲(chóng)與害蟲(chóng)防治專(zhuān)業(yè)，獲農(nóng)學(xué)博士學(xué)位。2005年-2010年美國(guó)范德比爾特大學(xué)從事博士后研究。長(zhǎng)期從事害蟲(chóng)化學(xué)生態(tài)學(xué)和功能基因組學(xué)的研究工作，提出以嗅覺(jué)受體為靶標(biāo)高通量篩選昆蟲(chóng)行為調(diào)控劑的新思路，研發(fā)了重要農(nóng)業(yè)害蟲(chóng)綠色防控新技術(shù)。主持國(guó)家自然科學(xué)基金杰出青年基金、國(guó)家基金重點(diǎn)項(xiàng)目、國(guó)家基金重點(diǎn)國(guó)際合作項(xiàng)目、國(guó)家重點(diǎn)研發(fā)計(jì)劃等項(xiàng)目。發(fā)表研究論文150余篇，其中以第一或者通訊作者在PNAS、Current Biology、Mole.Biol.Evol.、eLife等雜志上發(fā)表SCI論文80余篇，獲授權(quán)國(guó)家發(fā)明專(zhuān)利8件，主（參）編著作3 部。

工作經(jīng)歷：

2019.5-至今              中國(guó)農(nóng)業(yè)科學(xué)院（深圳）農(nóng)業(yè)基因組研究所       研究員，博士生導(dǎo)師

2011.1-至今              中國(guó)農(nóng)業(yè)科學(xué)院植物保護(hù)研究所                        研究員，博士生導(dǎo)師

2005.1-2010.12        中國(guó)農(nóng)業(yè)科學(xué)院植物保護(hù)研究所                        副研究員，碩士生導(dǎo)師

2005.3-2010.10        美國(guó)Vanderbilt大學(xué)                                         Senior/Research Associate

2002.9-2005.1          中國(guó)農(nóng)業(yè)科學(xué)院植物保護(hù)研究所                        助理研究員

2002.7-2002.9          中國(guó)農(nóng)業(yè)科學(xué)院植物保護(hù)研究所                        實(shí)習(xí)期

教育經(jīng)歷：

1999.9-2002.7        中國(guó)農(nóng)業(yè)科學(xué)院研究生院          獲博士學(xué)位

1996.9-1999.7        中國(guó)農(nóng)業(yè)科學(xué)院研究生院          獲碩士學(xué)位

1992.9-1996.7        安徽師范大學(xué)生物系                 大學(xué)本科

 研究領(lǐng)域：

研究方向：

實(shí)驗(yàn)室的主要研究方向是昆蟲(chóng)化學(xué)生態(tài)學(xué)和功能基因組學(xué)。目前的研究課題是：（1）昆蟲(chóng)的化學(xué)生態(tài)學(xué)機(jī)制和昆蟲(chóng)行為調(diào)節(jié)劑的開(kāi)發(fā)。這是為了利用組學(xué)、神經(jīng)生物學(xué)和結(jié)構(gòu)生物學(xué)對(duì)關(guān)鍵的化學(xué)傳感分子靶標(biāo)進(jìn)行功能表征，闡明昆蟲(chóng)嗅覺(jué)行為的機(jī)制，然后利用人工智能和高通量篩選開(kāi)發(fā)新的昆蟲(chóng)行為調(diào)節(jié)劑。（2） 昆蟲(chóng)RNAi的分子機(jī)制及其應(yīng)用。研究不同昆蟲(chóng)，特別是鞘翅目、鱗翅目和直翅目重要害蟲(chóng)RNAi差異的分子機(jī)制。同時(shí)，我們利用功能基因組學(xué)、合成生物學(xué)和納米材料等新技術(shù)開(kāi)發(fā)RNAi農(nóng)藥。

研究進(jìn)展：

深圳市科技計(jì)劃：該項(xiàng)目由深圳市科創(chuàng)委立項(xiàng)。該基金會(huì)的目的是通過(guò)功能基因組學(xué)開(kāi)發(fā)新技術(shù)，以環(huán)保的方式控制害蟲(chóng)。

（1） 對(duì)害蟲(chóng)基因組進(jìn)行高質(zhì)量測(cè)序和組裝。

（2） 識(shí)別害蟲(chóng)特定生物過(guò)程中的關(guān)鍵基因，如嗅覺(jué)行為或表型，作為分子靶標(biāo)。

（3） 開(kāi)發(fā)基于目標(biāo)的害蟲(chóng)防治技術(shù)，如昆蟲(chóng)行為調(diào)節(jié)劑或RNAi殺蟲(chóng)劑。

 代表論著：

代表論文：

1. Bing Wang, Wanying Dong, Huimin Li, Chiara D’Onofrio, Penghua Bai, Ruipeng Chen, Lulu Yang, Jinan Wu, Xiaoqing Wang, Bo Wang, Dong Ai, Wolfgang Knoll, Paolo Pelosi *, Guirong Wang*. Molecular basis of (E)-b-farnesene-mediated aphid location in the predator Eupeodes corolla.  Current Biology 2022, 32, 951–962.

2. Wang C, Zhang S, Guo MB, Hou XQ, Yang B, Wang GR*. Optimization of a pheromone lure by analyzing the peripheral coding of sex pheromones of Spodoptera frugiperda in China. Pest Manag Sci. 2022 Jul;78(7):2995-3004.

3. Mengbo Guo#, Lixiao Du#, Qiuyan Chen, Yilu Feng, Jin Zhang, Xiaxuan Zhang, Ke Tian, Song Cao, Tianyu Huang, Emmanuelle Jacquin-Joly, Guirong Wang*, Yang Liu*. Odorant receptors for detecting flowering plant cues are functionally conserved across moths and butterflies.  Molecular Biology and Evolution. 2021, 38(4): 1413-1427

4. Sai Zhang#, Shuwei Yan#, Zhixiang Zhang, Song Cao, Bin Li, Yang Liu*, Guirong Wang*. Identification and functional characterization of sex pheromone receptors in mirid bugs (Heteroptera: Miridae).  Insect Biochemistry and Molecular Biology. 2021, 136: 103621.

5. Song Cao#, Yang Liu#, Bing Wang, Guirong Wang*. A single point mutation causes one-way alteration of pheromone receptor function in two Heliothis species.  iScience. 2021, 24: 102981.

6. Shuai Liu, Hetan Chang, Wei Liu, Weichan Cui, Yang Liu, Yinliang Wang, Bingzhong Ren*, Guirong Wang*. Essential role for SNMP1 in the detection of sex pheromone components in Helicoverpa armigera. Insect Biochemistry and Molecular Biology. 2020, 127: 103485.

7. Yang Liu#, Hangwei Liu#, Hengchao Wang#, Tianyu Huang#, Bo Liu, Bin Yang, Lijuan Yin, Bin Li, Yan Zhang, Sai Zhang, Fan Jiang, Xiaxuan Zhang, Yuwei Ren, Bing Wang, Sen Wang, Yanhui Lu, Kongming Wu*, Wei Fan*, Guirong Wang*. Apolygus lucorum genome provides insights into omnivorousness and mesophyll feeding. Molecular Ecology Resources, 2021, 21: 287-300.

8. Lucie Bastin-Heline, Arthur de Fouchier, Song Cao, Fotini Koutroumpa, Gabriela Caballero-Vidal, Stefania Robakiewicz, Christelle Monsempes, Marie-Christine Francois, Tatiana Ribeyre, Annick Maria, Thomas Chertemps, Anne de Cian, William B Walker III, Guirong Wang*, Emmanuelle Jacquin-Joly*, Nicolas Montagne*. A novel lineage of candidate pheromone receptors for sex communication in moths. elife. 2019, 8: e49826.

9. Paolo Pelosi, Immacolata Iovinella, Jiao Zhu, Guirong Wang*, Francesca Romana Dani*. Beyond chemoreception: different tasks of soluble olfactory proteins in insects.  Biological Reviews. 2018, 93: 184-200

10. Hetan Chang, Yang Liu, Dong Ai, Xingchuan Jiang, Shuanglin Dong, Guirong Wang*. A pheromone antagonist regulates optimal mating time in the moth, Helicoverpa armigera. Current Biology, 2017, 27(11): 1610-1615

11. R Zhang, B Wang, G Grossi, P Falabella, Y Liu, S Yan, J Lu, J Xi, G Wang*. Molecular Basis of Alarm Pheromone Detection in Aphids. Current Biology. 2017, 27(1):55-61

12. Zhu J, S Arena, S Spinelli, D Liu, G Zhang, R Wei, C Cambillau, A Scaloni, G Wang^*, P Pelosi^*. Reverse Chemical ecology: Olfactory proteins from the giant panda and their interactions with putative pheromones and bamboo volatiles.  PNAS, 2017, 114(46): E9802-E9810.

13. Paolo Pelosi, Immacolata Iovinella, Jiao Zhu, Guirong Wang*, Francesca Romana Dani*. Beyond chemoreception: different tasks of soluble olfactory proteins in insects.  Biology Reviews. 2017. doi: 10.1111/brv.12339.

14. Bing Wang, Yang Liu * and Gui-Rong Wang*. Chemosensory genes in the antennaltranscriptome of two syrphid species,Episyrphusbalteatus and Eupeodes corolla(Diptera: Syrphidae). BMC Genomics (2017) 18:586

15. Jiao Zhu, Liping Ban, Li-Mei Song, Yang Liu, Paolo Pelosi*, Guirong Wang*. General Odorant-Binding Proteins and sex pheromone guide larvae of Plutella xylostella to better food.  Insect Biochemistry and Molecular Biology.  2016, 72:10-19.

16. J Zhu, I Iovinella, F Romana Dani, Y Liu, L Huang, Y Liu, C Wang, P Pelosi*, G Wang*. Conserved chemosensory proteins in the proboscis and eyes of Lepidoptera.IJBS, 2016 12(11): 1394-1404

17. J Wei, T Fu, D Cao, T Yang, Y Liu, G Wang*. A TRPA1 channel that senses thermal stimulus and irritating chemicals in Helicoverpaarmigera. Insect Molecular Biology. 2015, 24(4): 412-421.

18. Jin Zhang, Shuwei Yan, Yang Liu, Emmanuelle Jacquin-Joly, Shuanglin Dong, Guirong Wang*. Identification and Functional Characterization of Sex Pheromone Receptors in the Common Cutworm (Spodoptera litura). Chemical Senses. 2015, 40(1):7-16.

19. Liu C, Liu Y, Walker WB, Dong SL*, Wang GR*. Identification and functional characterization of sex pheromone receptors in beet armyworm Spodoptera exigua (Hübner).  Insect Biochemistry and Molecular Biology. 2013, 43: 747-754

20. Wang GR, Allison Carey, John R. Carlson and Laurence J. Zwiebel. The Molecular Basis of Odor Coding in Malaria Vector Mosquito Anopheles gambiae. PNAS  2010, 107(9):4418-23

21. Allison Carey, Guirong Wang, Chih-Ying Su, Laurence J. Zwiebel, and John R. Carlson. Odorant reception in the malaria mosquito Anopheles gambiae. Nature 2010 464(7285):66-71.

22. Wang GR, Y.T. Qiu, T. Lu, H. Kwon, R. J. Pitts, J.J. van Loon, W. Takken and L.J. Zwiebel.  Anopheles gambiae TRPA1 is a heat-activated channel expressed in thermosensitive sensilla of female antennae. European Journal of Neuroscience.  2009, 30: 967-974.

23. Y.F. Xia, Wang GR (first co-author), D Buscariollo, R.J. Pitts, H. Wegner and L.J. Zwiebel. The Molecular and Cellular Basis of Olfactory Behavior in Anopheles gambiae Larvae.  PNAS.  2008, 105(17):6433-8.

24. T. Lu, YT. Qiu, Wang GR (first co-author), J.Y. Young, M. Rutzler, H.W. Kwon, R. J. Pitts, J. J.A. van Loon, J. R. Carlson, W. Takken, and L. J. Zwiebel. Odor Coding in the Maxillary Palp of the Malaria Vector Mosquito Anopheles gambiae. Current Biology.  2007, 17(18): 1533-1544.

代表專(zhuān)利：

1. 王桂榮，王嬋，劉楊，楊斌，一種基于草地貪夜蛾性信息素的高效引誘劑及其應(yīng)用，中國(guó)：ZL202111509744.2

2. 王桂榮，楊斌，綠盲蝽decapentaplegic基因及其RNAi在害蟲(chóng)防控中的應(yīng)用，中國(guó)：ZL201810716459.X

3. 王桂榮，常賀坦，劉楊，艾東，鑒定一種物質(zhì)對(duì)昆蟲(chóng)行為是否有影響及有何種影響的方法，中國(guó)：ZL201710195931.5

4. 王桂榮，李峰奇，楊婷，劉楊，一種與萜烯類(lèi)化合物合成相關(guān)的蛋白及其應(yīng)用，中國(guó)：ZL201610078482.1

5. 王桂榮，李峰奇，楊婷，劉楊，一種與E-b-石竹烯和E-a-律草烯合成相關(guān)的蛋白及其應(yīng)用，中國(guó)：ZL 2016 1 0077850.0

王桂榮課題組更新于2023年11月