姓名：		蕭玉濤
	職稱：		研究員,，博士生導(dǎo)師
	電話/傳真：		0755-84235795
	電子郵件：		[email protected]
	實(shí)驗(yàn)室主頁(yè)：
	研究方向：		重要本土和入侵農(nóng)業(yè)害蟲適應(yīng)性進(jìn)化機(jī)制

 簡(jiǎn)歷介紹：

蕭玉濤,，研究員，博士生導(dǎo)師,。

現(xiàn)擔(dān)任中國(guó)農(nóng)業(yè)科學(xué)院農(nóng)業(yè)基因組研究所“農(nóng)業(yè)昆蟲基因組學(xué)”創(chuàng)新團(tuán)隊(duì)首席科學(xué)家,，長(zhǎng)期從事農(nóng)業(yè)昆蟲與害蟲防治研究工作,，圍繞草地貪夜蛾,、棉鈴蟲等重要農(nóng)業(yè)害蟲,，綜合運(yùn)用多組學(xué)手段和基因編輯等分子生物學(xué)技術(shù),，在農(nóng)業(yè)害蟲適應(yīng)性進(jìn)化機(jī)制研究方面取得了一系列重要成果。先后主持國(guó)家自然科學(xué)基金青年基金和面上項(xiàng)目,、轉(zhuǎn)基因新品種培育重大專項(xiàng)子課題,、科技創(chuàng)新2030重大項(xiàng)目課題、深圳市科創(chuàng)委基礎(chǔ)研究重點(diǎn)項(xiàng)目等16項(xiàng),；以通訊作者在The Innovation,、PNAS、Molecular Biology and Evolution,、Molecular Ecology Resources,、Molecular Ecology、BMC biology,、IBMB,、PMS等期刊發(fā)表多篇SCI論文，中文文章8篇,；授權(quán)國(guó)家發(fā)明專利6項(xiàng),；參加國(guó)際學(xué)術(shù)會(huì)議并作報(bào)告7次。

 課題組成員：

PI: 蕭玉濤（[email protected]）

兼職教授：David Goodwin Heckel（[email protected]）

副研究員：靳明輝（[email protected]）,，張磊（[email protected]）,，徐琦（[email protected]）。

科研助理：吳超（[email protected]）,，黃嘉琦（[email protected]）,。

博士后：劉振興 ([email protected]),，李洪冉（[email protected]），王鵬 （[email protected]）,，朱經(jīng)云（[email protected]）,，鄒路明（[email protected]），范文敏（[email protected]）,，史學(xué)濤（[email protected]）

博士生：梁馨月（[email protected]）,，單銀雪（[email protected]），彭炎（[email protected]）,，龍廣燕（[email protected]）,。

碩士生：王平（[email protected]），何艷瑾（[email protected]）,，張竹亭（[email protected]）,，劉學(xué)峰（[email protected]），彭捷（[email protected]）,，劉壯壯（[email protected]）,，王娜（[email protected]），劉欣燁（[email protected]）,，平君芬（[email protected]）,，趙崇君（[email protected]），Alexander Englem Yesaya（[email protected]）,，VIGAN Chess-Kadouste（[email protected]）,。

 研究領(lǐng)域：

研究方向：

農(nóng)業(yè)害蟲適應(yīng)性進(jìn)化是其暴發(fā)成災(zāi)的根本原因。課題組以農(nóng)業(yè)領(lǐng)域重要本土和入侵性害蟲棉鈴蟲,、草地貪夜蛾,、小地老虎等為研究對(duì)象，綜合運(yùn)用群體基因組學(xué),、關(guān)聯(lián)分析,、基因編輯、細(xì)胞生物學(xué),、生物測(cè)定等方法,，解析害蟲的環(huán)境適應(yīng)性進(jìn)化機(jī)制（抗藥性、Bt抗性,、耐寒性等）,，鑒定致害性新基因或位點(diǎn)，挖掘害蟲防控新靶標(biāo),，應(yīng)用于害蟲綠色防控新技術(shù)和新措施研發(fā),。

研究進(jìn)展：

1）重大農(nóng)業(yè)害蟲基因組圖譜繪制：結(jié)合PacBio、Nanopore,、Hi-C等技術(shù)完成草地貪夜蛾等害蟲的高質(zhì)量基因組圖譜,，揭示了入侵我國(guó)的草地貪夜蛾以“玉米型”遺傳背景為主導(dǎo)并明確其群體抗藥性特征,。相關(guān)研究成果發(fā)表在MER、BMC biology等期刊,。

2）害蟲農(nóng)藥及Bt抗性分子機(jī)制：首次闡釋害蟲通過(guò)Cad、ABCC2,、ABCC3,、ABCB6等基因多種類型變異介導(dǎo)的抗藥性機(jī)理，成功解析害蟲對(duì)Bt,、農(nóng)藥,、棉酚等殺蟲物質(zhì)產(chǎn)生抗性和交互抗性的新機(jī)制。相關(guān)研究成果發(fā)表在Ecology letters,、 eLife,、Plos pathogens、AEM,、IBMB,、PMS等昆蟲學(xué)TOP期刊。

3）重大農(nóng)業(yè)害蟲適應(yīng)性進(jìn)化機(jī)制：綜合運(yùn)用基因組學(xué),、種群遺傳學(xué)等技術(shù),，揭示重大農(nóng)業(yè)害蟲棉鈴蟲和亞州玉米螟環(huán)境適應(yīng)性進(jìn)化機(jī)制，相關(guān)研究成果發(fā)表在The Innovation,、Molecular Biology and Evolution等期刊,。

 代表論著：

代表論文：

1. Minghui Jin#; Yinxue Shan#; Yan Peng#; Wenhui Wang#; Huihui Zhang; Kaiyu Liu; David G. Heckel; Kongming Wu*; Bruce E. Tabashnik; Yutao Xiao*. Downregulation of a transcription factor associated with resistance to Bt toxin Vip3Aa in the invasive fall armyworm. Proceedings of the National Academy of Sciences of the United States of America, 2023, 140(44): e2306932120.

2. Minghui Jin#; Yan Peng#; Jie Peng#; Huihui Zhang; Yinxue Shan; Kaiyu Liu; Yutao Xiao*. Transcriptional regulation and overexpression of GST cluster enhances pesticide resistance in the cotton bollworm, Helicoverpa armigera (Lepidoptera: Noctuidae). Communications Biology, 2023, 6: 1064.

3. Xinyue Liang; Ping Wang; Lei Zhang; Zaiyuan Li; Yutao Xiao*. Determining the complete mitochondrial genome of Tethea albicostata (Lepidoptera: Drepanidae) and phylogenetic analysis. Mitochondrial DNA Part B-Resources, 2023, 8(9): 963-966.

4. Lei Zhang#, Zaiyuan Li#, Yan Peng#, Xinyue Liang, Kenneth Wilson, Gilson Chipabika, Patrick Karangwa, Bellancile Uzayisenga, Benjamin A. Mensah, Donald L. Kachigamba, Yutao Xiao*. Global genomic signature reveals the evolution of fall armyworm in the Eastern hemisphere. Molecular Ecology, 2023, 00, 1-16.

5. Kaikai Mao, Hongran Li, Jingyun Zhu, Minghui Jin, Peng Wang, Yan Peng, Yutao Xiao*. Rapid test to detect insecticide resistance in field populations of Spodoptera frugiperda (Lepidoptera: Noctuidae). Frontiers in Physiology, 2023, 14:1254765.

6. Minghui Jin#, Yinxue Shan#, Qi Li, Yan Peng, Yutao Xiao*. A novel Cry1A resistance allele of fall armyworm in the new invaded region. International Journal of Biological Macromolecules, 2023, 244: 125392.

7. Minghui Jin#, Henry L. North#, Yan Peng#, Hangwei Liu#, Bo Liu#, Ruiqing Pan#, Yan Zhou#, Weigang Zheng, Kaiyu Liu, Bo Yang, Lei Zhang, Qi Xu, Samia Elfekih, Wendy A. Valencia-Montoya, Tom Walsh, Peng Cui, Yongfeng Zhou, Kenneth Wilson, Chris Jiggins*, Kongming Wu*, Yutao Xiao*. Adaptive evolution to the natural and anthropogenic environment in a global invasive crop pest, the cotton bollworm. The Innovation, 2023, 4(4): 100454.

8. Ying Cheng#, Peng Wang#, Yuxiao Zeng, Wenwen An, Tao Wang, Yutao Xiao*. Characterization of five pigmentation genes as transgenic markers in Spodoptera frugiperda (Lepidoptera: Noctuidae). International Journal of Biological Macromolecules, 2023, 242(3): 124981.

9. Yan Peng#, Minghui Jin#, Zhimin Li#, Hongran Li#, Lei Zhang, Songmiao Yu, Zhuting Zhang, Ruyi Fan, Jimin Liu, Qi Xu, Kenneth Wilson, Yutao Xiao*. Population-genomics provide insights into the evolution and adaptation of the Asia corn borer. Molecular Biology and Evolution, 2023, 40(5): msad112.

10. Xinyue Liang, Lei Zhang, Zaiyuan Li, Yutao Xiao*. Characterization of the mitochondrial genome of the lawn cutworm Spodoptera depravata (Lepidoptera: Noctuidae). Mitochondrial DNA Part B-Resources, 2023, 8(2): 310-313.

11. Minghui Jin#, Bo Liu#, Weigang Zheng#, Conghui Liu#, Zhenxing Liu#, Yuan He#, Xiaokang Li, Chao Wu, Ping Wang, Kaiyu Liu, Shigang Wu, Hangwei Liu, Swapan Chakrabarty, Haibin Yuan, Kenneth Wilson, Kongming Wu*, Wei Fan*, Yutao Xiao*.Chromosome?level genome of black cutworm provides novel insights into polyphagy and seasonal migration in insects. BMC Biology, 2023, 21(1):2.

12. He Yuan#, Bojia Gao#, Chao Wu#, Lei Zhang, Hui Li, Yutao Xiao*, Kongming Wu*. Genome of the hoverfly Eupeodes corollae provides insights into the evolution of predation and pollination in insects. BMC Biology, 2022, 20: 157.

13. Yinxue Shan#, Minghui Jin#, Swapan Chakrabarty#, Bo Yang, Qi Li, Ying Cheng, Lei Zhang *, Yutao Xiao*. Sf-FGFR and Sf-SR-C Are Not the Receptors for Vip3Aa to Exert Insecticidal Toxicity in Spodoptera frugiperda. Insects, 2022, 13(6): 547.

14. Chongyu Liao, Dandan Zhang, Ying Cheng, Yongbo Yang, Kaiyu Liu, Kongming Wu*, Yutao Xiao*. Down-regulation of HaABCC3, potentially mediated by a cis-regulatory mechanism, is involved in resistance to Cry1Ac in the cotton bollworm, Helicoverpa armigera. Insect science, 2022, 0, 1-11.

15. Chao Wu#, Lei Zhang#, Bo Liu#, Bojia Gao, Cong Huang, Ji Zhang, Minghui Jin, Hanyue Wang, Yan Peng, Annabel Rice, Esmat Hegazi, Kenneth Wilson*, Pengjun Xu*, Yutao Xiao*. Genomic features of the polyphagous cotton leafworm Spodoptera littoralis. BMC Genomics, 2022, 23(1): 353.

16. Chongyu Liao, Minghui Jin, Ying Cheng, Yongbo Yang, Mario Soberón, Alejandra Bravo, Kaiyu Liu*, Yutao Xiao*. Bacillus thuringiensis Cry1Ac Protoxin and Activated Toxin Exert Differential Toxicity Due to a Synergistic Interplay of Cadherin with ABCC Transporters in the Cotton Bollworm. Applied and environmental microbiology, 2022, 88(7): e02505-21.

17. Qi Li#, Minghui Jin#, Songmiao Yu, Ying Cheng, Yinxue Shan, Peng Wang, Haibin Yuan*, Yutao Xiao*.Knockout of the ABCB1 gene increases susceptibility to emamectin benzoate, beta-cypermethrin and chlorantraniliprole in Spodoptera frugiperda. Insects, 2022, 13(2): 137.

18. Minghui Jin#, Yinxue Shan#, Yan Peng#, Ping Wang, Qi Li, Songmiao Yu, Lei Zhang*, Yutao Xiao*. An Integrative Analysis of Transcriptomics and Proteomics Reveals Novel Insights into the Response in the Midgut of Spodoptera frugiperda Larvae to Vip3Aa. Toxins, 2022, 14(1): 55.

19. Dandan Zhang#, Minghui Jin#, Yanchao Yang, Jianfeng Zhang, Yongbo Yang, Kaiyu Liu,Mario Sober′on, Alejandra Bravo, Yutao Xiao*, Kongming Wu*. Synergistic resistance of Helicoverpa armigera to Bt toxins linked to cadherin and ABC transporters mutations. Insect Biochemistry and Molecular Biology, 2021, 137: e103635.

20. Zaiyuan Li, Wenkai Wang, Yutao Xiao*, Lei Zhang*. Characterization of the mitochondrial genome of Spodoptera exempta (Lepidoptera: Noctuidae) from South Africa. Mitochondrial DNA Part B, 2021, 6(2): 370-372.

21. Yutao Xiao#, Wenjing Li#, Xianming Yang#, Pengjun Xu#, Minghui Jin, He Yuan, Weigang Zheng, Mario Soberón, Alejandra Bravo, Kenneth Wilson, Kongming Wu*. Rapid spread of a densovirus in a major crop pest following wide-scale adoption of Bt-cotton in China. eLife, 2021, 10: e66913.

22. Liu Yuanyuan, Jin Minghui, Wang Ling, Wang Haixia, Xia Zhichao, Yang Yongbo, Bravo Alejandra, Soberon Mario, Xiao Yutao*, Liu Kaiyu*. SfABCC2 transporter extracellular loops 2 and 4 are responsible for the Cry1Fa insecticidal specificity against Spodoptera frugiperda. Insect Biochemistry and Molecular Biology, 2021, 135.

23. Jin Minghui, Tao Jiahui, Li Qi, Cheng Ying, Sun Xiaoxu, Wu Kongming, Xiao Yutao*. Genome editing of the SfABCC2 gene confers resistance to Cry1F toxin from Bacillus thuringiensis in Spodoptera frugiperda. Journal of Integrative Agriculture, 2021, 20(3): 815-820.

24. Minghui Jin, Yanchao Yang, Yinxue Shan, Swapan Chakrabarty, Ying Cheng , Mario Soberón, Alejandra Bravo, Kaiyu Liu, Kongming Wu*, Yutao Xiao*. Two ABC transporters are differentially involved in the toxicity of two Bacillus thuringiensis Cry1 toxins to the invasive crop-pest Spodoptera frugiperda (J. E. Smith). Pest Management Science, 2021, 77(3): 1492-1501.

25. Zhang Lei#, Liu Bo#, Zheng Weigang#, Liu Conghui#, Zhang Dandan#, Zhao Shengyuan#, Li Zaiyuan, Xu Pengjun, Wilson Kenneth, Withers Amy, Jones M. Christopher, Smith A. Judith, Chipabika Gilson, Kachigamba L.Donald, Nam Kiwoong, Alencon Emmanuelle d’, Liu Bei, Liang Xinyue, Jin Minghui, Wu Chao, Chakrabarty Swapan, Yang Xianming, Jiang Yuying, Liu Jie, Liu Xiaolin, Quan Weipeng, Wang Guirong, Fan Wei*, Qian Wanqiang*, Wu Kongming*, Xiao Yutao*. Genetic structure and insecticide resistance characteristics of fall armyworm populations invading China. Molecular Ecology Resources, 2020, 20(6): 1682-1696.

26. Jin Minghui#, Cheng Ying#, Guo Xueqin#, Li Meizhi, Chakrabarty Swapan, Liu Kaiyu, Wu Kongming, Xiao Yutao*. Down-regulation of lysosomal protein ABCB6 increases gossypol susceptibility in Helicoverpa armigera. Insect Biochemistry and Molecular Biology, 2020, 122: 103387.

27. Zhang Lei, Wu Chao, Xiao Yutao*. Preference Assessment of White-backed Planthopper Feeding on Rice. JoVE-Journal of Visualized Experiments, 2020, 159: e59323.

28. Chakrabarty Swapan, Jin Minghui, Wu Chao, Chakraborty Panchali, Xiao Yutao*. Bacillus thuringiensis vegetative insecticidal protein family Vip3A and mode of action against pest Lepidoptera. Pest Management Science, 2020, 76(5): 1612-1617.

29. Zhang Lihua#, Lu Guoqing#, Huang Xinzheng#, Guo Huiming, Su Xiaofeng, Han Lida, Zhang Yongjun, Qi Zhi, Xiao Yutao*, Cheng Hongmei*. Overexpression of the caryophyllene synthase gene GhTPS1 in cotton negatively affects multiple pests while attracting parasitoids. Pest Management Sciences, 2020, 76(5): 1722-1730.

30. Wu Chao, Chakrabarty Swapan, Jin Minghui, Liu Kaiyu*, Xiao Yutao*. Insect ATP-Binding Cassette (ABC) Transporters: Roles in Xenobiotic Detoxification and Bt Insecticidal Activity. International Journal of Molecular Sciences, 2019, 20(11): 2829.

31. Jin Minghui, Liao Chongyu, Fu Xingxian, Holdbrook Robert, Wu Kongming, Xiao Yutao*. Adaptive regulation of detoxification enzymes in Helicoverpa armigera to different host plants. Insect Molecular Biology, 2019, 28(5): 628-636.

32. Xiao Yutao, Wu kongming*. Recent progress on the interaction between insects and Bacillus thuringiensis crops. Philosophical Transactions of The Royal Society B: Biological Sciences, 2019, 374: 1767.

33. Jin Minghui, Liao Chongyu, Chakrabarty Swapan, Wu Kongming, Xiao Yutao*. Comparative Proteomics of Peritrophic Matrix Provides an Insight into its Role in Cry1Ac Resistance of Cotton Bollworm Helicoverpa armigera. Toxins, 2019, 11(2): 92.

34. Jin Minghui, Liao Chongyu, Chakrabarty Swapan, Zheng Weigang, Wu Kongming, Xiao Yutao*. Transcriptional response of ATP-binding cassette (ABC) transporters to insecticides in the cotton bollworm, Helicoverpa armigera. Pesticide Biochemistry and Physiology, 2019, 154: 46-59.

35. Han Yongqiang; Wu Chao; Yang Lang; Zhang Deyong; Xiao Yutao*. Resistance to Nilaparvata lugens in rice lines introgressed with the resistance genes Bph14 and Bph15 and related resistance types. PLoS ONE, 2018, 13(6): e0198630.

36. Huang Xinzheng# , Xiao Yutao# , K?llner Tobias G., Jing Weixia, Kou Junfeng, Chen Jieyin, Liu Danfeng, Gu Shaohua, Wu Junxiang, Zhang Yongjun, Guo Yuyuan. The terpene synthase gene family in Gossypium hirsutum harbors a linalool synthase GhTPS12 implicated in direct defence responses against herbivores. Plant Cell & Environment, 2018, 41(1): 261-274.

37. Xiao Yutao, Dai Qing, Hu Ruqin, Pacheco Sabino, Yang Yongbo, Liang Gemei, Soberon Mario, Bravo Alejandra, Liu Kaiyu*, Wu Kongming*. A Single Point Mutation Resulting in Cadherin Mislocalization Underpins Resistance against Bacillus thuringiensis Toxin in Cotton Bollworm. Journal of Biological Chemistry, 2017, 292(7): 2933-2943.

38. Xiao Yutao#, Liu Kaiyu#, Zhang Dandan, Gong Lingling, He Fei, Soberoacuten Mario, Bravo Alejandra Bravo, Tabashnik Bruce E., Wu Kongming*. Resistance to Bacillus thuringiensis mediated by an ABC transporter mutation increases susceptibility to toxins from other bacteria in an invasive insect. PLoS Pathogens, 2016, 12(2): e1005450.

39. Xiao Yutao#, Wang Qi#, Erb Matthias, Turlings Ted C J, Ge Linquan, Hu Lingfei, Li Jiancai, Han Xiu, Zhang Tongfang, Lu Jing, Zhang Guren, Lou Yonggen*. Specific herbivore-induced volatiles defend plants and determine insect community composition in the field , Ecology Letters, 2012, 15(10): 1130-1139.

40. 張磊，梁馨月,，張紀(jì),，蕭玉濤. 基于線粒體全基因組解析華北地區(qū)棉鈴蟲種群遺傳結(jié)構(gòu). 植物保護(hù)學(xué)報(bào)，2021,，48(5)：964-969.

41. 程英,，靳明輝，蕭玉濤. 鱗翅目昆蟲基因編輯技術(shù)研究進(jìn)展. 生物技術(shù)通報(bào),，2020,，36(03)：18-28.

42. 蕭玉濤，吳超,，吳孔明. 中國(guó)農(nóng)業(yè)害蟲防治科技70年的成就與展望. 應(yīng)用昆蟲學(xué)報(bào),，2019，56(06)：1115-1124.

43. 鄭偉剛,，靳明輝,，Swapan Chakrabarty，肖彬,，蕭玉濤,，袁海濱. 小地老虎不同組織表達(dá)差異揭示其翅發(fā)育機(jī)制. 生物技術(shù)通報(bào),，2019，35(10)：102-110.

44. 劉運(yùn)澤,，張丹丹,，曲愛軍，鄭方強(qiáng),，蕭玉濤.棉鈴蟲Bt抗感品系的轉(zhuǎn)錄組差異表達(dá)分析.山東農(nóng)業(yè)科學(xué),，2019，51(07)：5-9.

45. 張磊,，柳貝,，姜玉英，劉杰,，吳孔明,，蕭玉濤.中國(guó)不同地區(qū)草地貪夜蛾種群生物型分子特征分析. 植物保護(hù)，2019,，45(04)：20-27.

46. 吳超,，張磊，廖重宇,，吳孔明,，蕭玉濤.草地貪夜蛾對(duì)化學(xué)農(nóng)藥和Bt作物的抗性機(jī)制及其治理技術(shù)研究進(jìn)展. 植物保護(hù)學(xué)報(bào)，2019,，46(03)：503-513.

47. 張磊,，靳明輝，張丹丹,，姜玉英,，劉杰，吳孔明,，蕭玉濤. 入侵云南草地貪夜蛾的分子鑒定. 植物保護(hù),，2019，45(02)：19-24+56.

代表專利：

1. 蕭玉濤,，高博嘉,，桃蛀螟抗菌肽、基因及其產(chǎn)品與應(yīng)用,，中國(guó)：ZL 2022104227428.

2. 蕭玉濤,，程英，曾宇笑,，靳明輝,，廖重宇，sfIMP-X1基因及其在草地貪夜蛾遺傳防控中的應(yīng)用,，中國(guó)：ZL202110254411.3.

3. 蕭玉濤,，程英,，曾宇笑，靳明輝,，廖重宇,，一種靶向草地貪夜蛾Doublesex基因雌性特異E3外顯子的sgRNA及其應(yīng)用，中國(guó)：ZL 202110055205X.

4. 靳明輝,，蕭玉濤,，程英，廖重宇,，CYP6AB9基因和干擾棉鈴蟲棉酚代謝的dsRNA及二者在防治棉鈴蟲中的應(yīng)用，中國(guó)：ZL 201810424082.0.

5. 蕭玉濤,，靳明輝,，程英，廖重宇,，ABC轉(zhuǎn)運(yùn)蛋白作為靶點(diǎn)在防治害蟲上的應(yīng)用,，中國(guó)：ZL 201810903918.5.

6. 靳明輝，蕭玉濤,，程英,，廖重宇，一種棉鈴蟲CYP4L11基因的dsRNA及其應(yīng)用,，中國(guó)：ZL 201810385347.0.

7. 蕭玉濤,，張丹丹，胡朝興,，吳孔明,，棉鈴蟲轉(zhuǎn)運(yùn)蛋白ABCC2及其編碼基因和應(yīng)用，中國(guó)：ZL201510309514.X.

蕭玉濤課題組更新于2023年10月