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豬基因組設(shè)計(jì)育種創(chuàng)新團(tuán)隊(duì)

　　首席科學(xué)家：

　　唐中林，研究員,，博士生導(dǎo)師,。中國農(nóng)業(yè)科學(xué)院農(nóng)業(yè)基因組研究所首席科學(xué)家，動(dòng)物基因組研究中心主任,，2016年在哈佛大學(xué)做訪問學(xué)者,。承擔(dān)國家自然科學(xué)基金重點(diǎn)及面上項(xiàng)目、973子課題,、863重點(diǎn)和轉(zhuǎn)基因重大專項(xiàng)等國家級(jí)課題10余項(xiàng),，在Genome Biology等刊物發(fā)表SCI論文60余篇，獲國家技術(shù)發(fā)明二等獎(jiǎng),、省科技進(jìn)步獎(jiǎng),、中華農(nóng)業(yè)科技獎(jiǎng)、國家專利銀獎(jiǎng)等多項(xiàng)國家及省部級(jí)獎(jiǎng),，獲國家發(fā)明專利16項(xiàng),，軟件著作權(quán)7項(xiàng)，國際發(fā)明專利2項(xiàng),。2016年入選國家重大人才工程,。

　　研究方向：團(tuán)隊(duì)主要整合多組學(xué)數(shù)據(jù)、全基因組關(guān)聯(lián)分析與基因編輯技術(shù),，解析豬等動(dòng)物重要經(jīng)濟(jì)性狀形成分子機(jī)制,大規(guī)模挖掘關(guān)鍵基因和遺傳標(biāo)記，創(chuàng)新基因組設(shè)計(jì)育種的新理論和新方法,，開展豬育種新材料創(chuàng)制和品種改良,。

　　研究成績：團(tuán)隊(duì)繪制我國地方豬的高清基因組圖譜，揭示豬骨骼肌生長發(fā)育的轉(zhuǎn)錄組和甲基化圖譜,，大規(guī)模挖掘豬產(chǎn)肉等性狀相關(guān)的關(guān)鍵基因與調(diào)控元件,，開發(fā)復(fù)雜性狀新效應(yīng)基因的統(tǒng)計(jì)模型及算法，建立一種基因編輯系統(tǒng)并開發(fā)了檢測(cè)編輯效率的工具,。相關(guān)成果發(fā)表在Nature,、Science、Cell Research, Genomic Biology, Cell report和Development等國際重要刊物,。團(tuán)隊(duì)成員主持國家優(yōu)秀青年科學(xué)基金項(xiàng)目,、國家自然科學(xué)基金重點(diǎn)項(xiàng)目、國家自然科學(xué)基金面上及青年基金項(xiàng)目,、以及其他省部級(jí)項(xiàng)目等10余項(xiàng),。獲國家技術(shù)發(fā)明二等獎(jiǎng)、國家發(fā)明專利銀獎(jiǎng)等多項(xiàng)國家及省部級(jí)科技獎(jiǎng)勵(lì),，獲得和申報(bào)國家發(fā)明專利近20項(xiàng),，獲軟件著作權(quán)7項(xiàng),。

　　團(tuán)隊(duì)構(gòu)成：唐中林課題組、李奎課題組,、Yuwen Liu課題組,、易國強(qiáng)課題組

　　Pig Genome Design and Breeding Innovation Team

　　Chief Scientist:

　　Zhonglin Tang, Doctoral Advisor , research Professor of Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences (CAAS-AGIS), Director of the Animal Genomics Research Center. He was a visiting scholar at Harvard University in 2016. Zhonglin Tang has undertaken more than 10 projects supported by Natural Science Foundation of China (includes the National Key Project),973 Sub-topics, etc.. More than 60 papers were published on prestigious journals, such as Genome Biology. His team had won the National Technology Invention Award, Provincial Science and Technology Progress Award, China Agricultural Science and Technology Award,National Patent Silver Awardand other nationaland provincial awards. The team also obtained 16 national invention patents, 7 software copyrights and 2 international patents have been granted. Zhonglin Tang has been honored as a leader talent of National “Ten Thousand Talent Program”.

　　Research Field:

　　Our team mainly focused on pig genome design and breeding, integrate multi-omics data, genome-wide association analysis and gene-editing to analyze the molecular mechanisms for the formation of important economic traits in pigs and other animals, excavate key genes and genetic markers on a large scale, and innovate new theories and methods for genome design and pig breeding, and carry out new material creation and breed improvement in pig.

　　Achievements:

　　we drew a high-definition genome map of local pigs in China, reveals the transcriptome and methylation map of skeletal muscle growth and development, digs out key genes and regulatory elements related to traits such as pig meat production on a large scale, and develops statistical models of new effects genes for complex traits And algorithms, establish a gene editing system and develop tools for detecting editing efficiency. Besides, we shared the achievements in a series of top international journal such as Nature, Science, Cell Research, Genomic Biology, Cell report, Development etc. Grants includes the National Science Found for Excellent Young Scholars, the National Natural Science Foundation of China (National Key Projectand General?Program) more than 10 items. The team has achived a second prize for national technological inventions and the silver prize for national invention patents, also obtained and applied for nearly 20 national invention patents and 7 software copyrights.

豬基因組設(shè)計(jì)育種創(chuàng)新團(tuán)隊(duì)更新于2024年7月