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　　動(dòng)物表觀基因組學(xué)創(chuàng)新團(tuán)隊(duì)

　　

　　首席科學(xué)家：

　　高飛，研究員，博士生導(dǎo)師，農(nóng)業(yè)部農(nóng)業(yè)基因數(shù)據(jù)分析重點(diǎn)實(shí)驗(yàn)室副主任，中國農(nóng)業(yè)科學(xué)院青年英才，深圳市地方領(lǐng)軍人才，中國遺傳學(xué)會(huì)表觀遺傳專業(yè)委員會(huì)和中國實(shí)驗(yàn)動(dòng)物學(xué)會(huì)無菌動(dòng)物學(xué)會(huì)委員。長期從事發(fā)育和疾病過程的表觀遺傳控制；營養(yǎng)與菌群的表觀遺傳效應(yīng)等研究。在國際SCI學(xué)術(shù)期刊Genome Biology、Cell Research等發(fā)表論文51篇，其中第一或通訊作者論文34篇。

　　

　　研究方向：

　　團(tuán)隊(duì)主要研究動(dòng)物表觀基因組學(xué)新方法開發(fā)，哺乳動(dòng)物基因編輯方法優(yōu)化；營養(yǎng)與菌群的表觀遺傳效應(yīng)；構(gòu)建包括小鼠、豬等哺乳動(dòng)物的疾病模型，研究動(dòng)物發(fā)育和疾病過程的表觀遺傳調(diào)控。

 

　　研究成績：

　　團(tuán)隊(duì)開發(fā)了針對(duì)微量細(xì)胞的全基因組甲基化測序技術(shù)，建立了一種名為GOTI的新型脫靶檢測技術(shù)，顯著提高基因編輯技術(shù)的脫靶檢測靈敏性。團(tuán)隊(duì)與國內(nèi)外多個(gè)學(xué)校合作，在營養(yǎng)、腸道菌群對(duì)仔豬腸道發(fā)育的表觀遺傳效應(yīng)，哺乳動(dòng)物基因組編輯等方面進(jìn)行深入研究，先后在Science，Nature，Cell Research，Nature Methods，Genome biology等期刊發(fā)表一系列成果。

 

　　團(tuán)隊(duì)構(gòu)成：高飛課題組、左二偉課題組

 

　　Agricultural Genomics Technology Innovation Team

　　Chief Scientist

　　Fei Gao, Principle Investigator, Doctoral Advisor, deputy director of the Key Laboratory of Agricultural Genetic Data Analysis, Ministry of Agriculture, Young talent of the Chinese Academy of Agricultural Sciences, Leading Talent of Shenzhen, member of the Professional Committee of Epigenetics, Genetics Society of China and member of the Aseptic Animal Society, Chinese Association for Laboratory Animal Sciences. He prefers to focus on the role of epigenetics in animal development and pathology, especially how environmental factors such as nutrition and microbiota may affect host epigenetics. He has published 51 peer-reviewed papers on international journals including Genome Biology, Cell Research etc., 34 of which as the first or corresponding author.

 

　　Research Field

　　1）Development of new methodologies of animal epigenomics, optimization of gene editing method and technology in mammalian animals

　　2) Effects of nutrition and microbiota on animal epigenome

　　3) Construction of animal disease models in mice and pigs by genomic manipulation and study of epigenetic regulation of animal development and pathology

 

　　Achievements

　　We have developed a novel whole-genome bisulfite sequencing technology specifically designed for the minute amount of DNA sample, a method named “GOTI”, which significantly improved the sensitivity of off-target detection without prediction in advance. Our team collaborated with domestic and foreign universities to conduct in-depth studies on 1) the epigenetic effects of nutrition and gut microbiota on intestinal development of piglets and 2) mammalian genome editing, etc. We have already published a series of achievements in journals such as Science, Nature, Cell Research, Nature Methods, Genome Biology and so on.

　　

　　動(dòng)物表觀基因組學(xué)創(chuàng)新團(tuán)隊(duì)更新于2023年11月