李素華課題組

Li Suhua Lab

　　課題組長

李素華，研究員,，博士生導師,。2017年于清華大學獲得博士學位，2017-2020年在德國馬克斯·普朗克化學生態(tài)所進行博士后研究,。長期從事植物激素信號傳導和次生代謝調(diào)控研究,。共發(fā)表SCI收錄論文10余篇。以第一作者或通訊作者（含共同）在Nature,、Molecular Plant,、PLoS Biology、Plant Physiology,、Plant Journal等國際高水平雜志共發(fā)表論文7篇,。獲得過德國洪堡基金項目資助，獲得多項國家和省市級科研項目資助,。聯(lián)系方式：[email protected] （本實驗室長期招聘多組學生物信息分析,、植物抗蟲機制方向博士后）。

 

　　工作經(jīng)歷

　　2020.6 - 至今       中國農(nóng)科院深圳農(nóng)業(yè)基因組研究所      研究員

　　2017.4 - 2020.06     德國馬普化學生態(tài)所                      博士后

 

　　教育經(jīng)歷

　　2010.9 - 2017.1      清華大學          博士

　　2006.9 - 2010.9      中國農(nóng)業(yè)大學   學士

 

　　研究方向

植物和昆蟲是組成陸地生態(tài)系統(tǒng)的重要組成部分,。本課題組利用多組學分析,，結(jié)合分子生物學、遺傳學手段,，研究馬鈴薯,、煙草等植物與害蟲以及其他生物的互作機制,，解析互作中植物激素調(diào)控作用，挖掘抗性基因和次生代謝物,，為作物抗性育種提供新基因資源,。

 

　　研究進展　

該課題組長期從事期從事植物激素和作物抗蟲研究，與合作者共同揭示了新型植物激素獨腳金內(nèi)酯的受體感知和信號傳導機制,。并進一步對其生物學功能進行了研究,，發(fā)現(xiàn)了獨腳金內(nèi)酯通過和其他多種激素互作來共同調(diào)控多種植物代謝物的含量，從而促進植物抵御蟲害,，響應逆境脅迫的重要功能,。且開發(fā)了多種新型獨腳金內(nèi)酯和茉莉素相關(guān)的高活性人工合成分子，具有較高的潛在農(nóng)業(yè)應用價值,。

 

PI

Suhua Li, Principle Investigator. She received her Ph.D. degree in Biology from Tsinghua University in 2017. She subsequently worked as a postdoctoral researcher at Max Planck Institute for Chemical Ecology in Germany. She mainly focuses on exploring the function and the molecular mechanism of the transduction of plant hormones, as well as the regulatory mechanism of plant hormones on secondary metabolites. As the first author or co-author, she has published more than 10 papers in research journals such as Nature, Molecular Plant, PLoS Biology, Plant Physiology. She was awarded as an alumni member of Alexander von Humboldt Foundation. Email address: [email protected].

Working Experience

2020.6 – present     Agricultural Genomics Institute at Shenzhen - CAAS         Principal Investigator

2017.4 - 2020.6     Max Planck Institute for Chemical Ecology                          Postdoctor

 

Education

2010.9 - 2017.1      Tsinghua University                                                                 PhD

2006.9 – 2010.7      China Agricultural University                                                 Bachelor       

 

Research Interest

Plants and insects are important components of terrestrial ecosystems. By taking advantage of genomics, metabolomics with genetic methods, our group focuses on the interaction of plant with insects, such as the defense mechanism of potatoes and tobacco, the biosynthesis of secondary metabolites, identify more resistance genes and metabolites, to provide more genetic resources to potato breeding.　　

 

Major Achievements

The group leader has worked on plant hormones and insect resistance for a long time. We focused on two kinds of plant hormones, jasmonates and strigolactones, to reveal the molecular mechanisms of their signal transduction, and to investigate their regulatory functions on plant secondary metabolites. Together with collaborators, we revealed the perception mechanism of strigolactones with the receptors and the structure-activity relationships of strigolactones. We further investigated the ecological and physiological functions of strigolactones, such as regulating herbivore defense via manipulating defensive metabolites. In addition, we designed a serious of highly active jasmonate- and strigolactone-analogs, which are with potential possibility of agricultural applications.

 

Selected Publication

 *Co-first author, #Corresponding author

1. Zhu, J., Chen, R., Liu, J., Lin, W., Liang, J., Nauen, R., Li, S.*, Gao, Y.*. Presence of multiple genetic mutations related to insecticide resistance in Chinese field samples of two Phthorimaea pest species. Insects. 2024, 15(3): 194.

2. Kang, Z., Yan, Y., Lu, R., Dong, X., Xu, J., Zheng, D., Li, S.*, Gao, Q.*, Liu, S.*. Synthesis and biological profiling of novel strigolactone derivatives for Arabidopsis growth and development. Journal of Agricultural and Food Chemistry, 2023,71 (34): 12859-12874.

3. Li, S., Baldwin, G., Yang, C., Lu, R., Meng, S., Huang, J., Wang, M., Baldwin, IT. Field‐work reveals a novel function for MAX2 in a native tobacco's high‐light adaptions. Plant Cell and Environment, 2023, 47(1): 230-245.

4. Ye, Z., Lu, R., Li, C., Yang, D., Zeng, Z., Lin, W., Cheng, J., Yang, Z., Li, W., Gao, Y., Huang, S., Zhang, X.*, Li, S.*. Haplotype-resolved and chromosome-level genome assembly of Colorado potato beetle. Journal of Genetics and Genomics, 2023, 50(7): 532-535.

5. Li, Y., Li, S., Du, R., Wang, J., Li, H., Xie, D., Yan, J. Isoleucine enhances plant resistance against Botrytis cinerea via jasmonate signaling pathway. Frontiers in Plant Science, 2021, 12: 628328. (co-first and co-corresponding author)

6. Li, S., Li, Y., Chen, L., Zhang, C., Wang, F., Li, H., Wang, M., Wang, Y., Nan, F., Xie, D., Yan, J. Strigolactone mimic 2-nitrodebran one is highly active in Arabidopsis growth and development. The Plant Journal, 2021, 107(1): 67-76. 

7. Li, S., Joo, Y., Cao, D., Li, R., Lee, G., Halitschke, R., Baldwin, G., Baldwin, IT., Wang, M. Strigolactone signaling regulates specialized metabolism in tobacco stems and interactions with stem-feeding herbivores. PLoS Biology, 2020, 18 (8): e3000830. 

8. Yan, J., Li, S., Gu, M., Yao, R., Li, Y., Chen, J., Yang, M., Tong, J., Xiao, L., Nan, F.*, Xie, D.*. Endogenous bioactive jasmonate is composed of a set of (+)-7-iso-JA-amino acid conjugates. Plant Physiology, 2016, 172 (4): 2154-2164. (co-first author)

9. Li, S., Chen, L., Li, Y., Yao, R., Wang, F., Yang, M., Gu, M., Nan, F., Xie, D., Yan, J. Effect of GR24 stereoisomers on plant development in Arabidopsis. Molecular Plant, 2016, 9 (10): 1432-1435.

10. Yao, R., Ming, Z., Yan, L., Li, S., Wang, F., Ma, S., Yu, C., Yang, M., Li, C., Chen, L., Li, Y., Yan, C., Miao, D., Sun, Z., Yan, J., Sun, Y., Wang, L., Chu, J., Fan, S., He, W., Deng, H., Nan, F., Li, J., Rao, Z., Lou, Z.& Xie, D. DWARF14 is a non-canonical hormone receptor for strigolactone. Nature, 2016, 536 (7617): 469-73. (co-first author)

　　李素華課題組更新于2025年2月